Elucidation of the cancer progression through the a5b3 integrin pathway for establishment of a noval treatment for tumor growth

Research Project

Project/Area Number	15K20502
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Chiba University
Principal Investigator	MINAKAWA YASUYUKI 千葉大学, 大学院医学研究院, 特任助教 (30639787)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	α5β3integrin / Angiopietin-like3 / 口腔扁平上皮癌 / α5β3インテグリン / Angiopoietin-like　3
Outline of Final Research Achievements	Significant ANGPTL3 up-regulations were found in oral squamous cell carcinoma (OSCC) cell lines and primary OSCC patients compared with normal counterparts. Using ANGPTL3 knockdown cells, we revealed that decreased tumoral growth was closely correlated with cell-cycle arrest at the G1 phase via MAPK signaling cascades. In addition, ANGPL3 controlled α5β3 integrins in OSCCs, indicating that ANGPTL3 may play an important role in OSCC progression and diagnostic/therapeutic targets for the patients with OSCC.

Report

(3 results)