Development of new treatment by Exploration of novel EMT-associated molecule
| Project/Area Number |
15K20504
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔癌 / EMT |
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| Outline of Final Research Achievements |
We attempted to identify the molecule related to Epithelial-Mesenchymal Transition (EMT) generated in the process of cancer development in oral squamous cell carcinoma (OSCC), and to elucidate the molecular mechanism using an original functional screening method.MET proceeded from knocking down WNT10A in some of the OSCC cell lines, it was suggested that the reduction of WNT10A expression is involved in the generation of EMT in OSCC.
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| Academic Significance and Societal Importance of the Research Achievements |
癌遺伝子や癌抑制遺伝子による研究の進展により、「癌は遺伝子の病気」として発癌や癌の悪性形質獲得に関するメカニズムが徐々に解明され、予防・診断・治療に臨床応用されつつある。これまでのEMT の研究は、発現レベルでの検索から進められており、Functional genomics から展開する研究は少なかった。本研究の特色はE カドヘリン誘導性を有する分子スクリーニングを展開することで、創薬等の臨床応用が期待できる点である。
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Report
(5 results)
Research Products
(2 results)
