| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
In this study, we focused on the chronological changes in the expression pattern of VEGF-VEGFR signaling, and investigated the relationship between angiogenesis and early peripheral nerve regeneration after nerve transection in animal models.This study revealed that transection of inferior alveolar nerve (IAN) induced the expression of VEGF and VEGFR immediately after injury, prior to the commencement of nerve regeneration. A local administration of antibody to VEGF inhibited the expression of CD31 in the gap between proximal and distal stumps and the elongation of the nerve fibers from the proximal stump.These results suggest that immediate response of VEGF-VEGFR signaling to nerve injury plays a crucial role in local angiogenesis, resulting in a trigger for the regeneration of the nerve fibers in mouse IAN.
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