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Involvement of vascular endothelial growth factor in regeneration of injured peripheral nerve.

Research Project

Project/Area Number 15K20509
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNiigata University

Principal Investigator

KANEMARU Hiroko  新潟大学, 医歯学総合病院, 助教 (30464019)

Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords下歯槽神経 / 末梢神経損傷 / 神経再生 / VEGF / 末梢神経再生 / 歯学
Outline of Final Research Achievements

In this study, we focused on the chronological changes in the expression pattern of VEGF-VEGFR signaling, and investigated the relationship between angiogenesis and early peripheral nerve regeneration after nerve transection in animal models.This study revealed that transection of inferior alveolar nerve (IAN) induced the expression of VEGF and VEGFR immediately after injury, prior to the commencement of nerve regeneration. A local administration of antibody to VEGF inhibited the expression of CD31 in the gap between proximal and distal stumps and the elongation of the nerve fibers from the proximal stump.These results suggest that immediate response of VEGF-VEGFR signaling to nerve injury plays a crucial role in local angiogenesis, resulting in a trigger for the regeneration of the nerve fibers in mouse IAN.

Academic Significance and Societal Importance of the Research Achievements

末梢神経損傷後の知覚障害や疼痛には交感神経ブロックやレーザー照射など、血流増加を促すような治療法が従来から行われており、臨床的な治療効果をあげているものの、その詳細なメカニズムについてはわかっていない。本研究により軸索再生にはVEGF-VEGFRシグナルの活性化がその後の神経再生に重要であることが示され、これは上記の臨床的背景を裏付ける結果である。本研究結果は末梢神経再生の機序の解明につながるものであり、神経再生過程で生じる神経腫などの神経病変やそれに伴う難治性疼痛の治療法の開発へ貢献できると考えられる。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Semaphorin 3A Inhibits Nerve Regeneration During Early Stage after Inferior Alveolar Nerve Transection.2019

    • Author(s)
      Hiroko Kanemaru, Yurie Yamada, Atsushi ohazama, Takeyasu Maeda, Kenji seo
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 4245-4245

    • DOI

      10.1038/s41598-018-37819-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] <b>Vascularization via activation of VEGF-VEGFR signaling is essential for peripheral nerve r</b><b>egeneration </b>2018

    • Author(s)
      Yohei NISHIDA, Yurie YAMADA, Hiroko KANEMARU, Atsushi OHAZAMA, Takeyasu MAEDA, Kenji SEO
    • Journal Title

      Biomedical Research

      Volume: 39 Issue: 6 Pages: 287-294

    • DOI

      10.2220/biomedres.39.287

    • NAID

      130007528453

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2018-12-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Semaphorin 3A inhibits axon regeneration after trigeminal nerve transection2017

    • Author(s)
      Hiroko Kanemaru,Yurie Yamada,Atsushi Ohazama,Takeyasu Maeda,Kenji Seo
    • Organizer
      Annual meeting of the society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 下歯槽神経再生過程への Semaphorin3A の関与について2017

    • Author(s)
      金丸博子, 山田友里恵, 大峡 淳, 前田健康, 瀬尾憲司
    • Organizer
      平成29年度新潟歯学会第1回例会
    • Related Report
      2017 Research-status Report
  • [Presentation] 下歯槽神経切断後の軸索再生へのセマフォリン3A の関与2017

    • Author(s)
      金丸博子, 山田友里恵, 瀬尾憲司
    • Organizer
      ,第45回日本歯科麻酔学会総会・学術大会
    • Related Report
      2017 Research-status Report

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Published: 2015-04-16   Modified: 2022-01-27  

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