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The recovery of differentiation capacity and iPS induction efficiency of elder patient's dental pulp cells.

Research Project

Project/Area Number 15K20511
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionGifu University

Principal Investigator

IIDA KAZUKI  岐阜大学, 大学院医学系研究科, 助教 (30585237)

Research Collaborator KAWAGUCHI tomoko  
SUGIYAMA ken  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords歯髄細胞 / Sox11 / 骨分化 / iPS細胞
Outline of Final Research Achievements

DPCs (dental pulp cells) derived from elder patients were difficult to be used in a regenerative medicine, because of their low capacities of differentiation and induction to iPS cells. We thought gene introduction of Sox11, a key gene, to DPCs enhanced their capacities of differentiation and induction to iPS cells. Sox11 did not enhanced differentiation capacity to osteoblast lineages, but nerve lineages. This suggest Sox11 may help DPCs to be nerve cells. And, Sox11 did not enhanced induction efficiency to iPS cells.

Academic Significance and Societal Importance of the Research Achievements

DPCs(歯髄細胞)は、他の細胞へ変化する分化能力や万能細胞であるiPS細胞への高効率に変換する能力をもっているが、これは20代までの若年者のみであり、有病率の高い高齢者ではこれらの能力は低く、改善策が必要である。今回の研究ではkey geneとしてSox11に注目し、DPCsに遺伝子導入して、分化能やiPS誘導効率が向上するか解析した。結果として、Sox11はDPCsを神経細胞分化させるのに有用であることがわかり、神経再生などの研究や治療に役立つ可能性があることがわかった。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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