Development of new strategy for jaw deformity using CNP
Project/Area Number |
15K20516
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | CNP / 顎変形症 / 内軟骨性骨化 / 軟骨無形成症 |
Outline of Final Research Achievements |
Analysis of the μCT image of achondroplasia (Ach) model mice revealed midfacial hypoplasia in the sagittal direction and foramen magnum stenosis similarly to human. Both hypertrophic chondrocyte layers and proliferating chondrocyte layers the cartilage of the skull base of the Ach mice were narrowed, and early ossification with angiogenesis and apoptosis was found in the center of the cartilage of the skull base. The midfacial hypoplasia and the foramen magnum stenosis in the Ach mice could be significantly improved by the increase in the blood concentration of CNP. It was suggested that administration of CNP could improve the abnormalities of craniofacial morphology found in achondroplasia by promoting endochondral ossification in the cranial cartilage.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] A novel therapeutic strategy for midfacial hypoplasia using the CNP/GC-B system.2017
Author(s)
Nakao K, Yasoda A, Okubo Y, Yamanaka S, Koyama N, Osawa K, Isobe Y, Ikeno M, Fujii T, Miura M, Bessho K.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 29
Issue: 1
Pages: 10-16
DOI
Related Report
Peer Reviewed
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