Elucidation of the anti-inflammatory mechanism of dexmedetomidine - Analysis of arachidonate metabolism -
Project/Area Number |
15K20526
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Okayama University |
Principal Investigator |
Wakasugi Yuka 岡山大学, 医歯薬学総合研究科, 助教 (00749210)
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Research Collaborator |
MIYAKE Saki
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 歯学 / 薬理学 / デクスメデトミジン / 抗炎症作用 / 抗炎症 |
Outline of Final Research Achievements |
This study aimed to clarify the mechanism of anti-inflammatory effect of dexmedetomidine (DEX). First, anti-inflammatory effect of DEX in Raw264.7 mouse macrophages was examined. Next, it was hypothesized that the production of EETs (epoxyeicosatrienoic acids), which are considered to have anti-inflammatory effect, increased via the arachidonic acid cascade by DEX, resulting in anti-inflammatory effect. Although anti-inflammatory effect of DEX was observed in Raw 264.7, the administration of DEX inhibited the production of EET. Thus, the finding suggests that the anti-inflammatory effect of DEX possibly is not via EETs production, but other pathway.
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Report
(3 results)
Research Products
(3 results)
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[Presentation] The inhibitory effect of locally administered dexmedetomidine on acute inflammatory pain in rats.2015
Author(s)
Honda Y, Onishi Y, Higuchi H, Tanimura H, Kodama M, Mori M, Takaya K, Suda M, Yabuki-Kawase A, Yamane-Hirano A, Ishii-Maruhama M, Tomoyasu Y, Maeda S, Miyawaki.
Organizer
14th International Federation of Dental Anesthesiology Societies
Place of Presentation
Berlin, Germany
Year and Date
2015-10-09
Related Report
Int'l Joint Research