| Project/Area Number |
15K20526
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Wakasugi Yuka 岡山大学, 医歯薬学総合研究科, 助教 (00749210)
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| Research Collaborator |
MIYAKE Saki
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯学 / 薬理学 / デクスメデトミジン / 抗炎症作用 / 抗炎症 |
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| Outline of Final Research Achievements |
This study aimed to clarify the mechanism of anti-inflammatory effect of dexmedetomidine (DEX). First, anti-inflammatory effect of DEX in Raw264.7 mouse macrophages was examined. Next, it was hypothesized that the production of EETs (epoxyeicosatrienoic acids), which are considered to have anti-inflammatory effect, increased via the arachidonic acid cascade by DEX, resulting in anti-inflammatory effect. Although anti-inflammatory effect of DEX was observed in Raw 264.7, the administration of DEX inhibited the production of EET. Thus, the finding suggests that the anti-inflammatory effect of DEX possibly is not via EETs production, but other pathway.
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