| Project/Area Number |
15K20530
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Fukui Akiko 広島大学, 病院(歯), 歯科診療医 (50647550)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 血管作動性小腸ペプチド / VIP / 抗菌ペプチド / 創傷治癒 / 抗炎症作用 / VPAC / VEGF / 神経ペプチド / RT7 / GT1 / CXCL10 / VPAC１ / IFN-γ / 血管作動性小腸ぺプチド / 口腔粘膜上皮細胞 / 口腔粘膜線維芽細胞 / 抗菌作用 |
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| Outline of Final Research Achievements |
Neuropeptide and peptide hormones may have various function. Vasoactive intestinal peptide (VIP) is a neuropeptide, 28-amino acid neuropeptide, discovered as a vasodilator in the small intestine. In this study, we found that VIP increased the cell proliferation in oral keratinocytes and fibroblasts. The expression of VPAC1, VIP receptor was involved in cell migration activity and the expression of vascular endothelial grows factor in oral mucosal cells. Therefore, VIP may induce wound healing in oral mucosa.
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