Spatiotemporal Regulation of Adenoid Cystic Carcinoma Metastasis

• Project/Area Number: 15K20537
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: MURASE RYUICHI 愛媛大学, 医学部附属病院, 講師 (70452696)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 時空間制御機構 / 腺様嚢胞癌 / 血行性転移 / 上皮間葉移行

Outline of Final Research Achievements

During metastasis, dynamic molecular change is potentially implicated in cancer cells. We focused on the spatiotemporal regulation of adenoid cystic carcinoma (ACC) metastasis. Unlike squamous cell carcinoma, reversible epithelial-mesenchymal transition was not observed in ACC, while several RNAs expressed transiently. This result may indicate that a specific molecular mechanism is essential for disseminated ACC cells to proliferate and form metastases.