| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Receptor-binding cancer antigen expressed on SiSo cell (RCAS1) expression is reportedly correlated with clinico-pathological parameters in 15 human cancers, such as lymph node metastasis. After proteolytic process, membranous RCAS1 is secreted to serum from tumor cells in some cancer. In Our study, membranous pattern were expressed in oral squamous cell carcinoma (OSCC) cell lines, while soluble pattern was detected in supernatants. Soluble RCAS1 were significantly seen in high metastatic potential OSCC cell more than the others. In addition, RCAS1 expression is effected to migration ability, thus contributing to tumor lymph node metastasis. To elucidate mechanism of lymph node metastasis in OSCC, it was strongly suggested that functional regulation of RCAS1.
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