Research Project
Grant-in-Aid for Young Scientists (B)
The purpose of this study is to determine the functional role of the miRNA which is involved in 5-FU resistance in oral squamous cell carcinoma (OSCC). The human OSCC, and the 5-FU-resistant cell lines were used in this study. Then, on the basis of the miRNA microarray data that miR-30a is significantly upregulated in the resistant cell lines, we investigated the effects of miR-30a on 5-FU sensitivity. We produced two miR-30a overexpressing stable cell lines, and confirmed that both of them showed increased 5-FU resistance.Blood samples were collected before the administration of preoperative chemoradiotherapy for a routine laboratory analysis of the full blood count. Low expression of miR-1290 was significantly correlated with poor prognosis.
All 2016 2015
All Journal Article (6 results) (of which Peer Reviewed: 6 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (6 results)
BMC Cancer
Volume: 26 Issue: 1 Pages: 41-41
10.1186/s12885-016-2079-6
Br J Cancer
Volume: 115 Issue: 10 Pages: 1234-1244
10.1038/bjc.2016.327
Int. J. Oncol.
Volume: 49 Issue: 4 Pages: 1377-1384
10.3892/ijo.2016.3653
Int J Oral Maxillofac Surg
Volume: 45 Issue: 11 Pages: 1395-1399
10.1016/j.ijom.2016.04.014
Mol Clin Oncol
Volume: 5 Pages: 57-60
Volume: 16
