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Introduce of Protein sparing effect with intensive insulin therapy

Research Project

Project/Area Number 15K20547
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKagoshima University

Principal Investigator

Toya Akina  鹿児島大学, 医歯学域附属病院, 助教 (80593649)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords術後合併症 / インスリン / 外科的糖尿病 / GI療法 / IL-1β / IL-6 / TNF-α / 抗炎症作用
Outline of Final Research Achievements

Patients who received surgery of malignant tumor resection with the tissue reconstruction which takes 8 hours or more were enrolled in this study. We divided them into two groups, “Glycemic control group” (Group GI) and Non-management group (Group C).Blood glucose levels,WBC,CRP,TP,Alb,Cre,BUN,eGFR,IL-1β,TNF-α,temperature and postoperative complications were recorded.WBC and CRP increased in both groups.TP and Alb decreased in both groups.IL- 1βwas 0.967pg/mL at postoperative day 4 in Group GI , 0.293pg/mL at postoperative day1-4 in Group C.IL-6 was 49.50pg/mL at postoperative day 4 in Group GI, 277.040pg/mL at postoperative day1-4 in Group C.TNF-α was 3.030pg/mL at postoperative day 4 in Group GI, 2.532pg/mL at postoperative day1-4 in Group C.Some complications were obserbed in Group C.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2016

All Presentation (3 results)

  • [Presentation] ロクロニウムを希釈することによる血管痛減少効果2016

    • Author(s)
      遠矢明菜 真鍋 庸三, 岩本 繁, 大野 幸, 糀谷 淳, 杉村 光隆
    • Organizer
      日本歯科麻酔学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 左室拡張機能と加速度脈波パラメータ群の関係について2016

    • Author(s)
      糀谷 淳、大野 幸, 遠矢 明菜, 山下 薫, 真鍋 庸三, 杉村 光隆
    • Organizer
      日本歯科麻酔学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 静脈内鎮静法におけるRoot(Sed-Line+Radical-7)の使用経験2016

    • Author(s)
      是枝 清孝、 大野 幸, 山下 薫, 千堂 良造, 遠矢 明菜, 岐部 俊郎, 真鍋 庸三, 糀谷 淳, 杉村 光隆
    • Organizer
      日本歯科麻酔学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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