The effect of dental pulp stem cells on learning and memory impairment of dementia

• Project/Area Number: 15K20548
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kagoshima University
• Principal Investigator: Suzuki Hajime 鹿児島大学, 医歯学域歯学系, 助教 (10623340)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯髄幹細胞 / 病態モデル / 糖尿病 / 不安様行動 / 学習記憶障害

Outline of Final Research Achievements

There have been few reports on the therapeutic effects and mechanisms of pathological conditions by dental pulp stem cells. In this study, we examined the influence on the behavior by administration of dental pulp stem cells. It was confirmed that dental pulp stem cells did not improve behavior abnormalities in specific disease model animals. However, the tendency of triggering anxiety behavior was observed due to administration of dental pulp stem cells collected from a pathological model. It is suggested that the properties of dental pulp stem cells may change depending on the pathological condition and as a result may have some influence on the pathology.