| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The purpose of this study is to develop photodynamic hyperthermia therapy (PHT) by superselective intra-arterial infusion method using ICG as a new cancer treatment strategy applicable to superselective intra-arterial chemoradiotherapy . It is known that ICG generates heat by light irradiation. ICG is administered to the tumor feeding artery by using superselective intra-arterial infusion method, and it is accumulated at a high concentration in the tumor tissue. This method may improve the therapeutic effect of hyperthermia and photodynamic therapy.
In this study, animal experiments using nude mice subcutaneous tumor model suggest that forceful antitumor effect in PHT by ICG using superselective intra-arterial infusion method is obtained, which can be a promising treatment for oral cancer.
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