Development of Photodynamic Hyperthermia Therapy using ICG for oral cancer

• Project/Area Number: 15K20551
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: IIDA Masaki 横浜市立大学, 医学部, 助教 (70613511)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口腔癌 / インドシアニングリーン / 温熱療法 / 光線力学療法 / 光線力学温熱療法

Outline of Final Research Achievements

The purpose of this study is to develop photodynamic hyperthermia therapy (PHT) by superselective intra-arterial infusion method using ICG as a new cancer treatment strategy applicable to superselective intra-arterial chemoradiotherapy . It is known that ICG generates heat by light irradiation. ICG is administered to the tumor feeding artery by using superselective intra-arterial infusion method, and it is accumulated at a high concentration in the tumor tissue. This method may improve the therapeutic effect of hyperthermia and photodynamic therapy.
In this study, animal experiments using nude mice subcutaneous tumor model suggest that forceful antitumor effect in PHT by ICG using superselective intra-arterial infusion method is obtained, which can be a promising treatment for oral cancer.

Research Products

• [Journal Article] Clinical outcomes of retrograde intra-arterial chemotherapy concurrent with radiotherapy for elderly oral squamous cell carcinoma patients aged over 80?years old (2017)
  • Author(s): Hayashi Y, Mitsudo K, Sakuma K, Iida M, Iwai T, Nakashima H, Okamoto Y, Koizumi T, Oguri S, Hirota M, Kioi M, Koike I, Hata M, Tohnai I.
  • Journal Title: Radiation Oncology Volume: 12 Issue: 1 Pages: 112-112
  • DOI: 10.1186/s13014-017-0847-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for T2-4N0 tongue cancer: control of occult neck metastasis. (2017)
  • Author(s): Minamiyama S, Mitsudo K, Hayashi Y, Iida M, Iwai T, Nakashima H, Oguri S, Ozawa T, Koizumi T, Hirota M, Kioi M, Tohnai I
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 124(1) Issue: 1 Pages: 16-23
  • DOI: 10.1016/j.oooo.2017.02.004
  • Peer Reviewed
• [Journal Article] Increase of Peripheral Blood CD57+ T-Cells in Patients with Oral Squamous Cell Carcinoma. (2014)
  • Author(s): Iida M, Takayama E, Naganawa K, Mitsudo K, Adachi M, Baba J, Fujimoto-Muto M, Motohashi M, Mizuno-Kamiya M, Kawaki H, Kioi M, Ichinose M, Sumitomo S, Muramatsu Y, Shikimori M, Tohnai I, Kondoh N.
  • Journal Title: Anticancer Res Volume: 9 Issue: 1 Pages: 5729-5734
  • DOI: 10.2174/1874210601509010120
  • Peer Reviewed / Open Access
• [Presentation] Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: Analysis of therapeutic results in 112 cases. (2017)
  • Author(s): Mitsudo K, Koizumi T, Hayashi Y, Sugiura K, Iida M, Iwai T, Nakashima H, Oguri S, Kioi M, Hirota M, Tohnai I
  • Organizer: 6th World Oral Cancer Congress of the International Academy of Oral Oncology
  • Int'l Joint Research
• [Presentation] 進行口腔癌に対する超選択的動注化学放射線療法とハイパーサーミアの併用治療―下顎骨に接した頸部リンパ節転移に対する治療― (2017)
  • Author(s): 小泉敏之，光藤健司，飯田昌樹，佐藤 格，飯坂友宏，南山周平，林 雄一郎，野里朋代, 中鍛治里奈，大澤昂平，藤内 祝
  • Organizer: 日本ハイパーサーミア学会第34回大会
• [Presentation] 進行口腔癌に対する逆行性超選択的動注化学放射線療法とハイパーサーミアの併用療法 －頸部リンパ節転移に対する治療効果－ (2017)
  • Author(s): 野里朋代，光藤健司，小泉敏之，飯田昌樹，佐藤 格，飯坂友宏，南山周平，林 雄一郎，中鍛治里奈，大澤昂平，藤内 祝
  • Organizer: 日本ハイパーサーミア学会第34回大会
• [Presentation] Organ preservation with daily concurrent chemoradiotherapy using retrograde superselective intra-arterial infusion for locally advanced tongue cancer: analysis of therapeutic results in 101 cases. (2016)
  • Author(s): Mitsudo K, Oguri S, Minamiyama S, Iida M, Iwai T, Nakashima H, Koizumi T, Kioi M, Hirota M, Tohnai I
  • Organizer: 2016 American Society of Clinical Oncology (ASCO) Annual Meeting
  • Place of Presentation: McCormick Place(Chicago,U.S.A)
  • Year and Date: 2016-06-03
  • Int'l Joint Research
• [Presentation] Thermochemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral cancer with cervical lymph node metastases (2015)
  • Author(s): M. Iida, K. Mitsudo, T. Koizumi, H. Nakashima, T. Iwai, S. Oguri, M. Hirota, M. Kioi, I. Tohnai
  • Organizer: International Conference on Oral and Maxillofacial Surgery 2015
  • Place of Presentation: Melbourne Convention and Exhibition Centre（Melbourne）
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] 進行口腔癌頸部リンパ節転移症例に対する逆行性超選択的動注化学放射線療法とハイパーサーミアの併用療法 －病理結果と予後－ (2015)
  • Author(s): 飯田昌樹、光藤健司、小泉敏之、佐藤 格、中島英行、岩井俊憲、小栗千里、來生 知、廣田 誠、藤内 祝
  • Organizer: 日本ハイパーサーミア学会第32大会
  • Place of Presentation: KKRホテル大阪（大阪）
  • Year and Date: 2015-10-04