Functional roles of DSCAM and netrin-1 in bone metabolism

• Project/Area Number: 15K20556
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Saitama Medical University
• Principal Investigator: enoki yuichiro 埼玉医科大学, 医学部, 助教 (30734199)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: netrin / DSCAM / 骨芽細胞 / netrin-4 / Netrin-1 / Netrin-4 / 破骨細胞 / netrin1

Outline of Final Research Achievements

We found that netrin-4 promotes osteoblast differentiation and migration, suggesting that netrin-4 plays vital roles in regulating bone metabolism. We showed that netrin-4 does not interact with DSCAM receptor and DSCAM knockout mice exhibit normal bone phenotype, indicating that DSCAM receptor does not play essential roles in bone metabolism.

Research Products

• [Journal Article] Netrin-4 promotes differentiation and migration of osteoblasts. (2017)
  • Author(s): Enoki Y, Sato T, Kokabu S, Hayashi N, Iwata T, Yamato M, Usui M, Matsumoto M, Tomoda T, Ariyoshi W, Nishihara T, Yoda T.
  • Journal Title: In vivo (Athens, Greece) Volume: 31 Issue: 5 Pages: 793-799
  • DOI: 10.21873/invivo.11132
  • Peer Reviewed / Open Access
• [Journal Article] Functional Roles of Netrin-1 in Osteoblast Differentiation. (2017)
  • Author(s): Sato T, Kokabu S, Enoki Y, Hayashi N, Matsumoto M, Nakahira M, Sugasawa M, Yoda T.
  • Journal Title: In Vivo Volume: 31(3) Issue: 3 Pages: 321-328
  • DOI: 10.21873/invivo.11062
  • Peer Reviewed / Open Access / Acknowledgement Compliant