Functional roles of DSCAM and netrin-1 in bone metabolism
Project/Area Number |
15K20556
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Saitama Medical University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | netrin / DSCAM / 骨芽細胞 / netrin-4 / Netrin-1 / Netrin-4 / 破骨細胞 / netrin1 |
Outline of Final Research Achievements |
We found that netrin-4 promotes osteoblast differentiation and migration, suggesting that netrin-4 plays vital roles in regulating bone metabolism. We showed that netrin-4 does not interact with DSCAM receptor and DSCAM knockout mice exhibit normal bone phenotype, indicating that DSCAM receptor does not play essential roles in bone metabolism.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Netrin-4 promotes differentiation and migration of osteoblasts.2017
Author(s)
Enoki Y, Sato T, Kokabu S, Hayashi N, Iwata T, Yamato M, Usui M, Matsumoto M, Tomoda T, Ariyoshi W, Nishihara T, Yoda T.
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Journal Title
In vivo (Athens, Greece)
Volume: 31
Issue: 5
Pages: 793-799
DOI
Related Report
Peer Reviewed / Open Access
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