The study on accumulation of antiresorptive medicine in medication-related osteonecrosis of the jaw (MRONJ)

• Project/Area Number: 15K20559
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical University
• Principal Investigator: Hamada Hayato 東京医科大学, 医学部, 助教 (10421067)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 薬剤関連顎骨壊死 / ビスフォスフォネート / デノスマブ / 休薬 / 骨代謝

Outline of Final Research Achievements

Today medication-related osteonecrosis of the jaw (MRONJ) caused by bone resorption inhibitors is a serious problem.Changes in cancellous bone in osteomyelitis (OM) and MRONJ were compared using CT values. The MRONJ group was significantly higher (P <0.01) than the OM group. The OM group was significantly higher than the control group (P <0.05). However, there was no significant difference in the CT value of OM area compared with the non OM area. This suggests that bone hardening of cancellous bone by MRONJ is higher than that by OM.

Academic Significance and Societal Importance of the Research Achievements

MRONJの報告は増加の一途をたどっているが、発症機序や治療法においてエビデンスに乏しいのが現状である。われわれはMRONJとOMにおける海綿骨CT値を比較し、MRONJの方がOMよりもCT値が高値であることを確認した。このことより感染よりも薬剤の蓄積により骨硬化が進行することが示唆された。

Research Products

• [Journal Article] 埋入早期に骨髄炎を発症した即時埋入インプラントの1例 (2017)
  • Author(s): 浜田勇人、松尾朗、村田拓也、高橋英俊、近津大地
  • Journal Title: 日本顎顔面インプラント学会誌 Volume: 16 Pages: 33-37
  • Peer Reviewed / Open Access
• [Presentation] The evaluation of medication-related osteonecrosis of the jaw (MRONJ) and osteomyelitis of the mandible using computed tomography (2018)
  • Author(s): Hayato Hamada, Akira Matsuo, On Hasegawa, Masato Watanabe, Yoko Kawase-Koga, Daichi Chikazu
  • Organizer: 13th Asian Congress on Oral & Maxillofacial Surgery
  • Int'l Joint Research
• [Presentation] 飽和食塩溶液固定法遺体を用いたインプラント手術手技トレーニングの有用性 (2017)
  • Author(s): 渡辺 正人, 木本 明, 米山 勇哉, 浜田 勇人, 河野 通秀, 長谷川 温, 高橋 英俊, 古賀 陽子, 里見 貴史, 松尾 朗, 近津 大地
  • Organizer: 日本顎顔面インプラント学会
• [Presentation] バーチャルリアリティ画像によるインプラント埋入手術前のCT値の評価 (2017)
  • Author(s): 大場 英典, 浜田 勇人, 村田 拓也, 山川 樹, 近津 大地, 松尾 朗
  • Organizer: 日本口腔インプラント学会
• [Presentation] An evaluation of the bone status in Medication-Related Osteonecrosis of the mandible using Computed tomography (2016)
  • Author(s): 浜田勇人
  • Organizer: 第63回(公社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2016-11-25
• [Presentation] The evaluation method for early detection of Medication-Related Osteonecrosis of the mandible using computed tomography (2016)
  • Author(s): Hayato Hamada
  • Organizer: 23rd Congress of the European Association for Cranio Maxillofacial Surgery
  • Place of Presentation: The Queen Elizabeth 2 conference center London UK
  • Year and Date: 2016-09-13