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A study of mesenchymal stem cells transplantation for new treatment of Bisphosphonate-Related Osteonecrosis of the Jaw

Research Project

Project/Area Number 15K20562
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

MASHIMO Takayuki  日本大学, 歯学部, 非常勤医員 (30736450)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsBRONJ / 間葉系幹細胞 / 移植 / 抜歯窩 / ビスフォスフォネート製剤 / 骨髄由来間葉系幹細胞 / BRONJ / 細胞移植 / 顎骨壊死
Outline of Final Research Achievements

In the first year, I established methods of bone marrow-derived mesenchymal stem cell harvesting and transplantation into mice extraction sockets. Bone marrow-derived mesenchymal stem cell accelerated the bone marrow tissue formation in the mice extraction sockets. In addition, we success a preparation of bisphosphonate related osteonecrosis of the jaw (BRONJ) model mice with injecting intraperitoneally bisphosphonates, anticancer drugs and steroids into the mice. In the second year, bone marrow-derived mesenchymal stem cells were transplanted into the BRONJ model mice extraction sockets. As this time, Although, the results did not have significant difference, cell transplantation tended to improve BRONJ symptom.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 骨髄由来間葉系幹細胞を用いた歯周病に対する細胞治療の可能性2016

    • Author(s)
      井口 慎也,河野 英輔,鈴木 大悟,鶴町 仁奈,真下 貴之,鳥海 拓,磯川 桂太郎,新井 嘉則,佐藤 秀一,本田 雅規
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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