A study of mesenchymal stem cells transplantation for new treatment of Bisphosphonate-Related Osteonecrosis of the Jaw
| Project/Area Number |
15K20562
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ＢＲＯＮＪ / 間葉系幹細胞 / 移植 / 抜歯窩 / ビスフォスフォネート製剤 / 骨髄由来間葉系幹細胞 / BRONJ / 細胞移植 / 顎骨壊死 |
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| Outline of Final Research Achievements |
In the first year, I established methods of bone marrow-derived mesenchymal stem cell harvesting and transplantation into mice extraction sockets. Bone marrow-derived mesenchymal stem cell accelerated the bone marrow tissue formation in the mice extraction sockets. In addition, we success a preparation of bisphosphonate related osteonecrosis of the jaw (BRONJ) model mice with injecting intraperitoneally bisphosphonates, anticancer drugs and steroids into the mice. In the second year, bone marrow-derived mesenchymal stem cells were transplanted into the BRONJ model mice extraction sockets. As this time, Although, the results did not have significant difference, cell transplantation tended to improve BRONJ symptom.
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Report
(3 results)
Research Products
(1 results)
