| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Nucleus accumbens (NAc) in a terminal areas of mesolimbic dopaminergic neurons that project from the ventral tegmental area. NAc contains cholinergic neurons and animal experiments have shown that selective depletion of these neurons induces cognitive impairment, including memory deficits. Opioids are used to control persistent pain and amnesia is a recognized adverse effect. There are three subtypes of opioid receptors: mu, delta and kappa. Accumbal cholinergic neurons express delta and mu receptors that are thought to inhibit cholinergic activity. In present study, we investigated the roles of delta and mu receptors in the regulation of accumbal acetylcholine efflux of freely moving rats by in vivo microdialysis.
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