| Project/Area Number |
15K20565
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
NAKAHARA Ken 日本歯科大学, 新潟生命歯学部, 准教授 (20610257)
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| Research Collaborator |
IIZUKA Tateyuki
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 垂直的歯槽骨欠損 / 骨造成 / 骨補填材 / 歯科用インプラント |
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| Outline of Final Research Achievements |
In cases where vertical augmentation is necessary for implantation, bone substitution materials are very important for the prognosis of the treatment. To verify the efficiency of artificial bone materials for vertical bone grafting, we inserted two kinds of bone materials (α-TCP+HAp and β-TCP+HAp) into vertical bone defects created in the mandible in eight male Beagle dogs and analyzed samples harvested at six months after operations by means of micro-CT and histology.
All eight animals healed uneventfully and clinical signs of infection or dehiscence didn’t occur except for some fistulas near the grafted areas. On micro-CT images, both grafted materials were often resorbed, especially α-TCP samples occasionally showed remarkable resorption. Both artificial bone blocks remained unless bone remodeling in grafted area. The present study provided the information about bone substitutes to improve onlay bone grafting and its clinical application.
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