| Project/Area Number |
15K20569
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
IDE SHINJI 鶴見大学, 歯学部, 助教 (00611998)
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| Research Collaborator |
SATOMURA Kazuhito
TODA Reiko
TADOKORO Susumu
UMEKI Hirochika
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | メトレレプチン / 創傷治癒 / 口腔粘膜 / 皮膚 / レプチン |
|---|
| Outline of Final Research Achievements |
In this study, we examined the possibility of methleleptin as a wound healing promoting agent and aimed to clarify the mechanism of action of methleleptin in skin wound healing.
We found that the healing period can be shortened by administration of methleleptin in the skin wound healing process in chemical burn model mice. In addition, it was revealed that metreleptin has a proliferation promoting effect, a differentiation promoting effect, a migration promoting effect, and an angiogenesis promoting effect on human skin keratinocytes, and from these results, the wound healing promoting effect is keratinized It was thought that it was due to cell proliferation, differentiation, promotion of migration and promotion of angiogenesis. This study strongly suggested that methleleptin could be used as a wound healing promoter.
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