Does oral mucosal immune system contribute to Bisphosphonate-related osteonecrosis of the jaw?
| Project/Area Number |
15K20572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ビスホスホネート関連顎骨壊死 / マウスモデル / 口腔粘膜免疫 / 顎骨壊死 / 粘膜免疫 / 口腔粘膜 / 破骨細胞 / ビスホスホネート関連骨壊死 / 免疫細胞 |
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| Outline of Final Research Achievements |
The number of patients with bisphosphonate-related osteonecrosis of the jaw itself is small, symptoms are severe when it develops and there is no causal treatment. A lot of research has been done to clarify the mechanism of BRONJ and it has also been suggested that immune cells are involved in the phenotype of BRONJ symptoms. We studied using the ONJ mouse model as to which immune cell's response the BRONJ phenotype shows various symptoms.
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| Academic Significance and Societal Importance of the Research Achievements |
2014年に米国口腔顎顔面外科学会からMRONJに関するポジションペーパーが出され、従来の定義の変更がなされた。骨露出を認めるものに加え、骨露出のない瘻孔型のものも併記された。nBP長期使用患者数は年々累積していくなかTCRD-/-での結果は、gdT細胞と瘻孔型MRONJの表出との関連を示唆している。MRONJの病態解明にはgdT細胞の動態だけでなく口腔粘膜の免疫をつかさどるT細胞、B細胞、NK細胞の働きが鍵を握ると考える。そこで、成熟したT細胞・B細胞を欠損したRag2-/-マウスを使ってMRONJ症状の変化の検討を行った。
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] 重度歯周炎患者の血中サイトカインと歯周組織検査値との関係.2018
Author(s)
堀田敬史, 金山圭一, 竹内浩子, 森永啓嗣, 向井景祐, 木村洋子, 長谷川徹, 北後光信, 小足周平, 佐藤匠, 清水雄太, 伊神裕高, 澁谷俊昭.
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Journal Title
岐歯学誌
Volume: 45
Pages: 123-128
NAID
Related Report
Peer Reviewed
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[Journal Article] Study of a method to prepare novel carbonate-containing apatite porous bodies.2018
Author(s)
A Shibatsuji, K Kanayama, K Mukai, S Otari, H Morinaga, M Kitago, T Hasegawa, Y Kimura, H Takeuchi, Y Doi, T Shibutani.
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Journal Title
J Gifu Dent Soc
Volume: 45
Pages: 49-52
NAID
Related Report
Peer Reviewed
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[Journal Article] Histological study of the unsintered carbonate containing apatite porous body in beagle dog dorsal muscle.2018
Author(s)
A Shibatsuji, K Kanayama, K Mukai, S Otari, H Morinaga, M Kitago, T Hasegawa, Y Kimura, H Takeuchi, Y Doi, T Shibutani.
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Journal Title
J Gifu Dent Soc
Volume: 45
Pages: 53-58
NAID
Related Report
Peer Reviewed
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