Development of the dental pulpotomy materials applying polyphenol

• Project/Area Number: 15K20575
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: Nakamura Koichi 北海道大学, 歯学研究院, 助教 (50580932)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: catechin / nano porous silica / カテキン / 生活歯髄切断

Outline of Final Research Achievements

This study was intended to develop vital pulpotomy materials using catechin. I performed pulpotomy for the maxillary molar of the SD rat. I added epigallocatechin gallate of each density in zinc oxide eugenol cement after cutting in tooth coronal pulp under general anesthesia and covered the section. The change of the cell permeation more inflammatory than control (0% of catechin density) was slight with 0.1% of catechin density. The inflammatory cell permeation decreased in 1.0% of catechin density and 5.0%. I examined antibacterial action for Streptococcus mutans successively. In the case of 0.01%, it was restrained about half of degree quantity of bacteria culture 24 and 48 hours later the density of catechin.

Research Products

• [Journal Article] Charge and controlled release of epigallocatechin gallate by glass ionomer cement containing nanoporous silica particles (2017)
  • Author(s): Koichi Nakamura
  • Journal Title: nano biomedicine Volume: 9 Pages: 29-34
  • NAID: 130006415667
  • Peer Reviewed