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epigenetic mechanism of osteoblastic bone formation in mechanical stress

Research Project

Project/Area Number 15K20576
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

KERA YOUHEI  東北大学, 歯学研究科, 大学院非常勤講師 (90647950)

Co-Investigator(Renkei-kenkyūsha) YAMAMOTO TERUKO  東北大学, 大学院歯学研究科, 名誉教授 (00127250)
ITO ARATA  東北大学, 大学院歯学研究科, 大学院非常勤講師 (10805914)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsエピジェネティクス / エピジェネティック
Outline of Final Research Achievements

Osterix is essential transcription factor for osteoblast differentiation which promotes differentiation from preosteoblast to mature osteoblast by activation of several osteoblastic genes. In this study, we investigated mechanism of Osterix expression by Smad3 and MATII in mouse preosteobalastic cell line(MC3T3-E1 cell).Smad3 and MATII interact with each other and repress expression of Osterix. MATII is enzyme which has relation to transmethylation reactions involving histones, so these findings may suggest that this complex regulates Osterix through the mechanism including histone methylation.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] Diamond Blackfan 貧血を有する患者の頭蓋・顔面の特徴について2015

    • Author(s)
      解良洋平、北浦英樹、後藤まき、佐々木聡史、真山敦、伊藤新、山本照子
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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