| Project/Area Number |
15K20578
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨 / メカニカルストレス応答 / アドヘレンスジャンクション |
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| Outline of Final Research Achievements |
In this study, the involvement of adherens junction (AJ) in the respose to mechanical stress in oteocytes and osteoblasts was examined. In both osteocytes and osteoblasts, the expression of vinculin and the percentage of responsive cells were comparable in medium density and high density culture conditions, whereas in low density culture conditions, both were lowered. In addition, the inhibition of AJ formation resulted in a decrease in the percentage of responsive cells in medium density and high density culture conditions. These findings suggest that AJ is involved in cell mechanosensing system in bone.
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