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Role of IGF-I in morphogenesis of bioengineered teeth

Research Project

Project/Area Number 15K20579
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

YOSHIDA MICHIKO  東北大学, 大学病院, 助教 (80746818)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords再生歯胚 / IGF-I / エナメル結節 / FGF4 / マイクロアレイ
Outline of Final Research Achievements

We reported that the IGF-I treatment increased the size and cusp number of bioengineered teeth. However, the biological mechanisms of IGF-I on the bioengineered teeth morphology remain unclear. In this study, we examined the biological mechanisms underlying the effect of IGF-I on the bioengineered teeth morphology. Microarray analysis was performed using dental epithelial cells derived from tooth germs. The IGF-I treated dental epithelial cells expressed high level of various factors which are expressed during tooth development. Moreover, the proliferation and differentiation of the IGF-I treated dental epithelial cells were significantly upregulated. The number of the enamel knot increased in the IGF-I treated bioengineered teeth. These data suggest that IGF-I is involved in the biological mechanisms during tooth development.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] IGF1による再生歯の形態制御とそのメカニズムの解析2016

    • Author(s)
      大柳俊仁、竹下信郎、関大輔、原真美子、池田悦子、高野郁子、清流正弘、吉田倫子、山本照子
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 機械的刺激が促す骨形成過程における前駆骨芽細胞凝集へのCCN2/CTGFの影響2016

    • Author(s)
      竹下信郎、関大輔、清流正弘、木村晴地、高野郁子、大柳俊仁、吉田倫子、長谷川正和、山本照子
    • Organizer
      第8回日本CCNファミリー研究会
    • Place of Presentation
      岡山、岡山大学鹿田キャンパス内(医学部基礎研究棟1階大学院セミナー室)
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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