Construction of efficient orthodontic movement under the occlusal hypofunctional condition focusing on VEGF / VEGFR

• Project/Area Number: 15K20582
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: USUMI-FUJITA Risa 東京医科歯科大学, 歯学部附属病院, プロジェクト助教 (90706946)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 咬合刺激低下 / 廃用性萎縮 / 歯科矯正 / VEGF / LIPUS / 咬合機能低下歯

Outline of Final Research Achievements

Reduced occlusal stimuli are widely known to induce atrophic changes in the periodontal ligament (PDL) and alveolar bone. When compared with that of functional teeth, the PDL in occlusal hypofunctional teeth is thinner and bone formation and density are lower. Mechanical stress plays an important role in the homeostasis of PDL and alveolar bone remodeling.In this study, it was assumed that low-intensity pulsed ultrasound (LIPUS) exposure has recovery effects on the hypofunctional PDL and interradicular alveolar bone (IRAB). According to the results of micro-CT and qRT-PCR analysis, LIPUS exposure reduced the atrophic changes of alveolar bone by inducing the upregulation of periostin and CTGF expression to promote PDL healing after induction of occlusal hypofunction.

Research Products

• [Journal Article] Low-intensity pulsed ultrasound reduces periodontal atrophy in occlusal hypofunctional teeth. (2017)
  • Author(s): Kasahara Y, Usumi-Fujita R, Hosomichi J, Kaneko S, Ishida Y, Shibutani N, Shimizu Y, Okito A, Oishi S, Kuma Y, Yamaguchi H, Ono T.
  • Journal Title: The ANGLE ORTHODONTIST Volume: 印刷中 Issue: 5 Pages: 709-716
  • DOI: 10.2319/121216-893.1
  • Peer Reviewed / Open Access
• [Presentation] 矯正的歯の移動時におけるKi67およびLGR5陽性歯根膜細胞の局在変化 (2017)
  • Author(s): 細道 純, 鈴木 拓海, 渋谷 直樹, 細野 香澄, 山口 博之, 隈 陽一郎, 金香 佐和, 笠原 由紀, 大石 修史, 臼見 莉沙, 清水 康広, 小野 卓史
  • Organizer: 第76回日本矯正歯科学会大会
• [Presentation] LIPUS照射は咬合刺激低下歯の歯周組織を回復する (2016)
  • Author(s): 笠原 由紀, 臼見 莉沙, 隈 陽一郎, 大石 修史, 沖藤 明日香, 清水 康弘, 渋谷 直樹, 石田 雄之, 金香 佐和, 細道 純, 小野 卓史
  • Organizer: 第75回日本矯正歯科学会大会
  • Place of Presentation: 徳島県徳島市
  • Year and Date: 2016-11-07
• [Presentation] Effect of low-intensity pulsed ultrasound on periodontal tissues in occlusal hypofunctional teeth (2016)
  • Author(s): Yuki Kasahara, Risa Usumi-Fujita, Jun Hosomichi, Sawa Kaneko, Yuji Ishida, Naoki Shibutani, Yasuhiro Shimizu, Asuka Okito, Shuji Oishi, Yoichiro Kuma, and Takashi Ono.
  • Organizer: 38 Annual Scientific Conference on Dental Research
  • Place of Presentation: Vietnam・Ho Chi Minh City
  • Year and Date: 2016-04-04
  • Int'l Joint Research
• [Presentation] Effect of low-intensity pulsed ultrasound on periodontal tissues in occlusal hypofunctional teeth (2016)
  • Author(s): Yuki Kasahara, Risa Usumi-Fujita, Jun Hosomichi, Sawa Kaneko, Yuji Ishida, Naoki Shibutani, Yasuhiro Shimizu, Asuka Okito, Shuji Oishi, Yoichiro Kuma, and Takashi Ono.
  • Organizer: The 38th Annual Scientific Conference on Dental Research
  • Place of Presentation: Ho Chi Minh city, Vietnam
  • Int'l Joint Research