| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Reduced occlusal stimuli are widely known to induce atrophic changes in the periodontal ligament (PDL) and alveolar bone. When compared with that of functional teeth, the PDL in occlusal hypofunctional teeth is thinner and bone formation and density are lower. Mechanical stress plays an important role in the homeostasis of PDL and alveolar bone remodeling.In this study, it was assumed that low-intensity pulsed ultrasound (LIPUS) exposure has recovery effects on the hypofunctional PDL and interradicular alveolar bone (IRAB). According to the results of micro-CT and qRT-PCR analysis, LIPUS exposure reduced the atrophic changes of alveolar bone by inducing the upregulation of periostin and CTGF expression to promote PDL healing after induction of occlusal hypofunction.
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