| Project/Area Number |
15K20586
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Naka Shuhei 大阪大学, 歯学研究科, 助教 (10589774)
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| Research Collaborator |
NAKANO Kazuhiko 大阪大学, 歯学研究科, 教授 (00379083)
NOMURA Ryota 大阪大学, 歯学研究科, 准教授 (90437385)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 非アルコール性脂肪肝炎 / う蝕原性細菌 / コラーゲン結合タンパク / 肝臓細胞 / 脂肪酸 / Streptococcus mutane / 肝臓培養細胞 / 高分子タンパク抗原 / Streptococcus mutans / Protein Antigen |
|---|
| Outline of Final Research Achievements |
The mechanism of aggravation of non-alcoholic steatohepatitis caused by Streptococcus mutans, a major pathogen of dental caries, was investigated focusing on the cell surface 120-kDa collagen-binding protein (Cnm protein) and 190-kDa Protein Antigen (PA). In hepatic cells with accumulated oleic acid, a type of unsaturated fatty acids, S. mutans demonstrated an ability to attach the hepatic cells via Cnm protein. In addition, bacterial adhesion to unsaturated fatty acids occurred via PA antigen, causing a prominent increase in bacterial adhesion to hepatic cells, thus leading to aggravation of non-alcoholic steatohepatitis.
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