| Project/Area Number |
15K20595
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Sumi Keisuke 広島大学, 医歯薬保健学研究院(歯), 助教 (00707078)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 間葉系幹細胞 / 走化性 / 未分化間葉系幹細胞 / 破骨細胞 |
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| Outline of Final Research Achievements |
As an effect of MSCs on the differentiation of osteoclasts, it was found that promotion of blood vessel - inducing ability is observed but it inhibits osteoclast differentiation. And as a result of examining the influence of MSCs on the chemotaxis of RAW 264, it was revealed that MSCs affect chemotaxis by RAW 264 through signal transduction via CCL2-CCR2 interaction. From in vitro results, we examined the accumulation of RAW 264 in the MSCs transplantation area using skull defect model mouse and found extensive RAW 264 accumulation in the MSCs transplanted group.
From these results, it is suggested that MSCs may be involved in bone remodeling by affecting chemotaxis of surrounding cells.
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