| Project/Area Number |
15K20598
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
KONDO Yoshio 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30581954)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 感染性心内膜炎 / レンサ球菌 |
|---|
| Outline of Final Research Achievements |
Infective endocarditis is an infectious disease that forms warts in the endocardium, and the causative bacteria are pointed out as oral cavity-derived virulence streptococci. In this study, we compared genomes with non-pathogenic strains and Streptococcus oralis strain NS308 isolated from endocarditis lesion, and investigated the involvement in pathogenicity. As a result of analysis using the next generation sequencer, it was possible to obtain a full-length genome sequence. Based on this, comparing of the non-pathogenic strain S. oralis Uo5 and NS308 revealed that there are 340 NS308-specific genes and 69 of which are foreign genes. It seems that these are related to the acquisition of the pathogenicity in this bacterium, and further investigation will be necessary.
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