| Project/Area Number |
15K20599
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAMURA Aya 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (50711959)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 咀嚼 / マウス |
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| Outline of Final Research Achievements |
In this study, we developed masticatory hypofunctional models using botulinum neurotoxin type A injection into the masseter or temporalis muscle, and administered the anabolic steroid having the muscle enhancing action. We evaluated the effect of stimulating muscle function in hypofunction and the effect on stomatognathic function and dentofacial morphology with growth.
In the masticatory hypofunctional model, the muscle activity was significantly smaller and growth of mandible was reduced, which suggesting that the chewing efficiency decreased with changes in the jaw trajectory pattern. Although the growth of mandibular morphology tended to recover, adequate recovery of morphology around the mandibular condyle was not observed when steroids are administered to the hypofunctional model.
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