Relationship between oral function including salivation and cognitive function: Animal model and optogenetics
| Project/Area Number |
15K20603
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Okayama University (2017)
Kagoshima University (2015-2016) |
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Principal Investigator |
Ueda Hirotaka 岡山大学, 医歯薬学総合研究科, 助教 (10583445)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 唾液分泌 / 嚥下 / 内臓感覚 / 迷走神経 / 神経生理学 |
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| Outline of Final Research Achievements |
Vagal afferent stimulation significantly increased salivation and swallowing-like events in a frequency-dependent manner. A muscle relaxant, vecuronium bromide, diminished the swallowing-like response but did not affect salivation. Moreover, the tissue blood flow rate of the body surface increased according to the frequency of the vagus nerve stimulation. These results indicate that visceral sensation induces salivation and swallowing-like events in anesthetized rodents through vagal afferent activation.
These findings might contribute a new application of vagus nerve stimulation as to enhancing oral function.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats2017
Author(s)
Mitoh, Y., Ueda, H., Ichikawa, H., Fujita, M., Kobashi, M., Matsuo, R.
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Journal Title
Autonomic Neuroscience
Volume: 206
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access
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