Undifferatiation ability of dental pulp cells of deciduous teeth under hypoxia
| Project/Area Number |
15K20615
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
KAWAI Saki 大阪歯科大学, 歯学部, 助教 (70707067)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯髄 / 乳歯 / 低酸素 / 分化 |
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| Outline of Final Research Achievements |
Cell proliferation and differentiation of dental pulp cells in deciduous teeth (SHEDs) are greater than those of dental pulp cells in permanent teeth. And in recent study, it was suggested that dental pulp cells incubated under hypoxia can maintain ability of stem cells. I created the hypothesis that hypoxia can increase differentiation ability and examined cell proliferation, the gene expressions of undifferentiation markers(Oct3/4、sox2、c-Myc) and differentiations of adipocytes under hypoxia and normoxia. Hypoxia didn't affect cell proliferations of SHEDs. It increased the gene expression of Oct3/4, sox2 and c-Myc, and enhanced adipogenic differentiation under hypoxia. These results suggested that hypoxia enhances the differentiation ability of SHEDs.
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Report
(4 results)
Research Products
(3 results)
