| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Cell proliferation and differentiation of dental pulp cells in deciduous teeth (SHEDs) are greater than those of dental pulp cells in permanent teeth. And in recent study, it was suggested that dental pulp cells incubated under hypoxia can maintain ability of stem cells. I created the hypothesis that hypoxia can increase differentiation ability and examined cell proliferation, the gene expressions of undifferentiation markers(Oct3/4、sox2、c-Myc) and differentiations of adipocytes under hypoxia and normoxia. Hypoxia didn't affect cell proliferations of SHEDs. It increased the gene expression of Oct3/4, sox2 and c-Myc, and enhanced adipogenic differentiation under hypoxia. These results suggested that hypoxia enhances the differentiation ability of SHEDs.
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