Analysis of anti-inflammatory effect of vitaminD against periodonthopathic bacteria

Research Project

Project/Area Number	15K20619
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Periodontology
Research Institution	Niigata University
Principal Investigator	NONAKA Yukari 新潟大学, 医歯学総合研究科, 日本学術振興会特別研究員 (40710520)
Project Period (FY)	2015-03-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	ビタミンD / 歯周病 / 抗炎症作用
Outline of Final Research Achievements	Vitamin D is a nutrient involved in maintenance of bone homeostasis. The purpose of this study is to clarify the anti-inflammatory effect of vitamin D against periodontal pathogenic bacterial infection. Active vitamin D, 1,25(OH)2D3 couldn’t suppress the inflammatory response induced by periodontal pathogenic bacterial LPS in macrophages. Furthermore, wound healing assay was performed using Epi4 cells derived from human gingival epithelial cells, but wound healing promoting effect was not observed by addition of active vitamin D.

Report

(4 results)