| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In many inflammatory diseases, which affect connective tissues and bacterial infection-induced inflammatory periodontal disease, so-called periodontitis, tissues destruction is likely to be mediated by a variety of proteolytic enzymes which act in a synergistic manner to degrade connective tissue components including collagen and fibronectin.
In the study, by weak chronic inflammatory mice model, we examined IL-6 concentration and cathepsinBand L activity in the serum. We examined the effects of IL-6 on the secretion of pro-cathepsin B and L activity.The cathepsinB activity of patients are measured, and compared to healthy people. We demonstrated that it is upregulated to cathepsinB activity in the serum gingivitis patients.Our findings indicate that cathepsinB would be a therapeutic target for IL-6-induced tissue destruction in periodontitis.
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