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Application to the periodontium of the periodontal ligament cells spheroid sheet

Research Project

Project/Area Number 15K20626
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionKyushu Dental College

Principal Investigator

Hanatani Tomoya  九州歯科大学, 歯学部, 助教 (60649250)

Co-Investigator(Renkei-kenkyūsha) USUI Michihiko  九州歯科大学, 歯周病学分野, 准教授 (10453630)
ARIYOSHI Wataru  九州歯科大学, 感染分子生物学分野, 准教授 (40405551)
NAKATOMI Mitsushiro  九州歯科大学, 解剖学分野, 講師 (10571771)
NAKAZAWA Kohji  北九州市立大学, 国際環境工学部, 教授 (00304733)
Research Collaborator MORITANI Yuki  九州歯科大学, 歯周病学分野
SANO Kotaro  九州歯科大学, 歯周病学分野
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords歯根膜細胞スフェロイド / 歯根膜スフェロイド
Outline of Final Research Achievements

I collected periodontium from a human evulsion tooth. And I succeeded in making periodontal ligament cells spheroids. After comparing the osteogenesis of the monolayer culture periodontal ligament cells with the periodontal ligament cells spheroids, the RUNX2, COL1, ALP, OPN, BSP, OCN significantly showed high expression in a periodontal ligament cells spheroids.
In a mouse calvarial bone defect model, the newly formed bone mass, the percentage of defect closure, the percentage of newly formed bone area were significantly high in periodontal ligament cells spheroids group.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] 歯根膜細胞スフェロイドは骨分化能を増強する2016

    • Author(s)
      森谷 友貴、臼井 通彦、花谷 智哉、佐野 孝太朗、西原 達次、中島 啓介
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] スフェロイド培養が歯根膜細胞の骨分化能に及ぼす影響2016

    • Author(s)
      森谷 友貴、臼井 通彦、花谷 智哉、佐野 孝太朗、中冨 満城、有吉 渉、西原 達次、中澤 浩二、中島 啓介
    • Organizer
      日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      長崎
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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