Analysis of transcription factors involved in the differentiation induction of periodontal tissue constituent cells

Research Project

Project/Area Number	15K20631
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Periodontology
Research Institution	Nihon University
Principal Investigator	TAKAI Hideki 日本大学, 松戸歯学部, 講師 (30453898)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	転写因子 / 分化誘導
Outline of Final Research Achievements	Establishment of periodontal tissue regeneration therapy is important to understand the biological properties of the periodontal tissue component cells. We were searched HPDL is induced to what kinds of phenotype cells by suppressed the specifically expressed transcription factors at periodontal tissue. Result of suppression the specifically expressed transcription factor at periodontal tissue, siTwist2 increased Sox5 mRNA and protein levels. moreover, siKLF12 incresed Sox2 and KLF4 mRNA level, it increased KLF4 protein levels. we suggested that HPDL could be induced to different nature cell by suppressed the specifically expressed transcription factors at periodontal tissue.

Report

(3 results)