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Effect of IL-1 beta and CX3CR1 signaling in bone resorption of Periodontitis.

Research Project

Project/Area Number 15K20633
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionKansai Medical University

Principal Investigator

SAWADA Shunsuke  関西医科大学, 医学部, 助教 (60711075)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords慢性歯周炎 / サイトカイン / CX3CR1 / FKN / 骨吸収 / CX3CL1 / イメージング / FLK / fractalkine / Fractalkine / 歯槽骨吸収 / Gingival Fibroblasts / Periodontitis
Outline of Final Research Achievements

The study showed thepossibility of relationship between periodontitis and CX3CR1 signaling. Further study will be needed.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] VEGF-C and TGF-β reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes.2016

    • Author(s)
      Igarashi Y, Chosa N, Sawada S, Kondo H, Yaegashi T, Ishisaki A.
    • Journal Title

      Int J Mol Med.

      Volume: 37(4) Issue: 4 Pages: 1005-1013

    • DOI

      10.3892/ijmm.2016.2502

    • NAID

      120006334508

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Establishment of mesenchymal stem cell lines derived from the bone marrow of GFP-transgenic mice exhibiting diversity in intracellular TGF-β and BMP signaling.2016

    • Author(s)
      Sawada, S., Chosa, N., Takizawa, N., Yokota, J., Igarashi, Y., Tomoda, K., Kondo, H., Yaegashi, T., and Ishisaki, A.
    • Journal Title

      Mol. Med. Rep.

      Volume: 13 Issue: 3 Pages: 2023-2031

    • DOI

      10.3892/mmr.2016.4794

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 義歯装着のためのスペースの狭小化に対応した下顎顎義歯の1例2015

    • Author(s)
      澤田俊輔,兒島由佳
    • Journal Title

      顎顔面補綴

      Volume: 38(2) Pages: 47-51

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 歯肉の口腔粘膜疾患2015

    • Author(s)
      澤田俊輔、兒島由佳、友田幸一
    • Journal Title

      ENTONI

      Volume: 178 Pages: 26-32

    • Related Report
      2015 Research-status Report
  • [Presentation] 基礎ハンズオンセミナー 基礎研究も裾野を広げる ③ブースC siRNAを用いた遺伝子ノックダウンの基礎と応用2017

    • Author(s)
      神田晃, 小林良樹, 澤田俊輔, 尹泰貴, 岩井大, 中村銀二, 中山岳
    • Organizer
      第56回日本鼻科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 開口障害に対する内視鏡下歯科治療の可能性2016

    • Author(s)
      澤田俊輔、河岡有美、兒島由佳
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉、幕張メッセ国際会議場・国際展示場
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 鼻・副鼻腔組織を用いた基礎研究のすすめ方 1.ブースA「ウエスタンブロット法の基礎と応用」2016

    • Author(s)
      神田晃、小林良樹、澤田俊輔、尹 泰貴、牛山正人、西濱健、河田淳、田中聡子
    • Organizer
      第55回日本鼻科学会
    • Place of Presentation
      栃木県総合文化センター、宇都宮
    • Year and Date
      2016-10-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 顎顔面補綴領域での内視鏡応用の有効性2016

    • Author(s)
      澤田俊輔、兒島由佳
    • Organizer
      第33回顎顔面補綴学会総会学術大会
    • Place of Presentation
      新潟大学、新潟
    • Year and Date
      2016-06-03
    • Related Report
      2016 Research-status Report
  • [Presentation] GFPマウス骨髄由来間葉系幹細胞の分化能と遺伝子解析2016

    • Author(s)
      澤田俊輔、帖佐直幸、兒島由佳、朝子幹也、友田幸一、佐々木大輔、八重柏隆、石崎明
    • Organizer
      日本再生医療学会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 当科での内視鏡下歯科治療の新しい試み2015

    • Author(s)
      澤田俊輔、河岡有美、兒島由佳、友田幸一
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Endoscope Assisted Dental Surgery2015

    • Author(s)
      Shunsuke Sawada, Yuka Kojima, Mikiya Asako, Koichi Tomoda
    • Organizer
      The 32nd Congress of the Pan-Pacific Surgical Association Japan Chapter
    • Place of Presentation
      Honolulu Hawaii U.S.A.
    • Year and Date
      2015-09-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 関西医大付属病院での内視鏡下歯科治療の新たな試み2015

    • Author(s)
      澤田 俊輔、兒島由佳
    • Organizer
      第58回秋期日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松、浜松
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 術後の瘢痕拘縮によりデンチャースペース確保に苦慮した下顎顎義歯の1例2015

    • Author(s)
      澤田 俊輔、兒島由佳
    • Organizer
      第32回日本顎顔面補綴学会
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2015-06-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 関西医科大学歯科口腔外科における新規開設以来の周術期口腔機能管理2015

    • Author(s)
      澤田 俊輔、河岡有美、兒島由佳
    • Organizer
      第46回日本口腔外科学会近畿支部学術集会
    • Place of Presentation
      兵庫医科大学、西宮
    • Year and Date
      2015-06-13
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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