| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In a pilot study, we showed that tagatose at relatively higher concentration existed in saliva collected from adults with good oral hygiene. Here, we examined the probiotic effect of tagatose on oral microflora to maintain healthy conditions. Salivary metabolome analysis showed that a prediction model of periodontal inflammation severity could be constructed with several salivary metabolites including tagatose. In addition, our in vitro study showed that some oral bacteria were suppressed their growth and biofilm development under tagatose stress.
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