Elucidation of the actual situation and the risk factor of the human papilloma virus infection involved in the oral cavity, pharynx cancer

• Project/Area Number: 15K20644
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Kyushu University
• Principal Investigator: Takeuchi Kenji 九州大学, 歯学研究院, 助教 (10712680)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: ヒトパピローマウイルス / 口腔がん / 歯学 / 唾液

Outline of Final Research Achievements

This study estimated the prevalence of high-risk human papillomavirus (HPV) infection and determined distinct risk factors for high-risk HPV infection in a community-dwelling adults aged 40-69 years. Among 574 respondents (269 men and 305 women), high-risk HPV infection was found in 25 respondents (4.4%). In a multivariate logistic regression model, higher plaque score was significantly associated with greater odds of high-risk HPV infection (plaque score >1, odds rario = 3.49, 95% confidence interval= 1.24-9.81). These findings suggest that plaque score is an important predictor of high-risk HPV infection and maintenance of oral hygiene may contribute to prevention of oral cavity, pharynx cancer in Japanese adults.

Research Products

• [Journal Article] Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study. (2016)
  • Author(s): Takeshita T, Kageyama S, Furuta M, Tsuboi H, Takeuchi K, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y.
  • Journal Title: Science Reorts Volume: 6 Issue: 1 Pages: 1-11
  • DOI: 10.1038/srep22164
  • Peer Reviewed / Open Access