| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Periodontal disease has been reported to increase a risk factor for various systemic diseases, including arteriosclerosis, diabetes and rheumatoid arthritis. There are also reports suggesting an association with pancreatic disease, but the mechanism is not clear. In this study, we examined the effect of periodontal pathogens, P. gingivalis LPS on the pancreas in a mouse model system that does not cause acute inflammation in various organs. The gene expression of the pancreas was exhaustively analyzed in this model. By qPCR the expression level of Ighg3 and Igk mRNAs in the experimental group were significantly higher than in the control.
These results indicate that LPS from P. gingivalis may affect immunological diseases in the pancreas.
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