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The method of minimize environmental exposure by the hazardous drugs -Safe handling of oral hazardous drugs by simple suspension method-

Research Project

Project/Area Number 15K20716
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Clinical nursing
Research InstitutionKitasato University

Principal Investigator

Aoki Manahito  北里大学, 薬学部, 助教 (80458760)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsHazardous Drugs / 経管投与 / 簡易懸濁法 / 環境曝露 / 職業曝露 / 経口抗がん薬 / 清掃処理法 / 配合変化 / Hazardous Drugs / 曝露 / 内服HD / 経口抗がん剤 / 懸濁液のpH
Outline of Final Research Achievements

There is currently limited information available regarding exposure to oral hazardous drugs (HD). Therefore, through visual inspection of potential exposure routes such as gloves, preparatory tables, and bedsides, we devised recommended countermeasures to prevent environmental exposure to oral HD administered via enteral feeding tubes. Upon examining the effectiveness of the recommended countermeasures, results demonstrated that exposure to HD among nurses had decreased in comparison to conventional countermeasures. Using clopidogrel sulfate, we examined the degree of incompatibility in the solution used for the simple suspension method and investigated whether countermeasures to exposure affected the amount of drug administered by enteral feeding. Environmental exposure was observed in the packaging machine used during pulverization of oral HD. We showed that wiping more than twice with a damp cloth made with polypropylene was effective in removing drug contamination.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Products Report
  • Research Products

    (11 results)

All 2021 2019 2018 2017 2016 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Mixture of clopidogrel bisulfate and magnesium oxide tablets reduces clopidogrel dose administered through a feeding tube2021

    • Author(s)
      Aoki M, Naya M, Arima S, Shinohara K, Kato M, Shibuya K, Ohtawa M, Nagamitsu T, Otori K
    • Journal Title

      Journal of Pharmaceutical Health Care and Sciences

      Volume: 7:18 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s40780-021-00202-1

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Measures against Exposure during Administration of Hazardous Drugs through a Feeding Tube2019

    • Author(s)
      Aoki M, Hamasaki Y, Naya M, Shishikura H, Kato M, Shibuya K, Aoyagi M, Otori K
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 11 Pages: 1823-1829

    • DOI

      10.1248/bpb.b19-00343

    • NAID

      130007740633

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-11-01
    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] メトトレキサート錠およびシクロホスファミド錠の粉砕調剤における分包機の汚染除去に効果的な清掃法の検討2019

    • Author(s)
      青木 学一, 久保田 聡, 今野 友貴, 大和田 真未, 小田 さつき, 横田 訓男, 柴﨑 淳, 渋谷 清, 尾鳥 勝也
    • Journal Title

      日本病院薬剤師会雑誌

      Volume: 55 Pages: 273-278

    • NAID

      40021829181

    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] 飛散したロイケリン散10%の環境曝露に配慮した清掃処理法―調剤現場での実施例―2016

    • Author(s)
      青木学一,戸根奈津子,金澤温子,満木由布菜,吉田涼平,渋谷清,久保田理恵,酒向孫市,小宮山貴子
    • Journal Title

      日本病院薬剤師会雑誌

      Volume: 52 Pages: 287-291

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Hazardous Drugs簡易懸濁時のフラッシュ用注入器における曝露対策の有用性と経管投与量の検討2018

    • Author(s)
      納谷翠,青木学一,濵﨑優実,有馬志保,加藤雅大,宍倉大樹,渋谷清,長光亨,青柳明子,尾鳥勝也
    • Organizer
      医療薬学フォーラム2018(第26回クリニカルファーマシーシンポジウム)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸化マグネシウム錠との同時懸濁によるクロピドグレル硫酸塩錠の経管投与量への影響2017

    • Author(s)
      青木学一,加藤雅大,有馬志保,長井賢一郎,長光亨,尾鳥勝也
    • Organizer
      第27回日本医療薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 内服HDの簡易懸濁時における経管栄養シミュレータとリボフラビン製剤を用いた視覚的な環境曝露の実態調査と曝露対策の検討2017

    • Author(s)
      濵﨑優実,青木学一,納谷翠,宍倉大樹,加藤雅大,渋谷清,青柳明子,尾鳥勝也
    • Organizer
      医療薬学フォーラム2017(第25回クリニカルファーマシーシンポジウム)
    • Related Report
      2017 Annual Research Report
  • [Presentation] エンドキサン錠調剤時のパッカー型分包機の汚染状況と清掃法の検討2016

    • Author(s)
      青木学一,渋谷清,田中庸一,長谷川亜矢子,野本亜紀子,柴﨑淳,久保田理恵
    • Organizer
      第26回 日本医療薬学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 配合変化回避のための先発医薬品と後発医薬品の簡易懸濁法pHの比較2016

    • Author(s)
      青木学一,加藤雅大,篠原花織,安藤航,柴﨑淳,塩見めぐみ,田中庸一,渋谷清,久保田理恵,小宮山貴子
    • Organizer
      医療薬学フォーラム2016(第24回クリニカルファーマシーシンポジウム)
    • Place of Presentation
      滋賀県立芸術劇場 びわ湖ホール(滋賀県)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Research-status Report
  • [Presentation] クロピドグレル硫酸塩錠と酸化マグネシウム錠の同時懸濁時の配合変化に関する検討2016

    • Author(s)
      篠原花織,青木学一,田中庸一,加藤雅大,安藤航,塩見めぐみ,柴﨑淳,渋谷清,久保田理恵,小宮山貴子
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Remarks] 北里大学 研究者情報管理KERIDシステムホームページ

    • URL

      http://kerid-web.kitasato-u.ac.jp/Profiles/34/0003364/profile.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report 2015 Research-status Report

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Published: 2015-04-16   Modified: 2023-03-30  

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