To detect the affects of maternal exposure of OH-PCBs during pregnancy on metabolic pathway and disruption of reproductive hormones

• Project/Area Number: 15K20825
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine; Hygiene and public health
• Research Institution: Hokkaido University
• Principal Investigator: Sachiko ITOH 北海道大学, 環境健康科学研究教育センター, 特任講師 (90580936)
• Project Period (FY): 2015-03-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: OH-PCB / 性ホルモン / 胎児期曝露 / 出生コホート / 一塩基多型 / 環境疫学 / 予防医学 / 社会医学

Outline of Final Research Achievements

Evidence on the toxicity of hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) for reproductive hormones is limited. In addition,there was no statistical difference between any of the Single Nucleotide Polymorphism（SNPs） related to metabolic pathway and OH-PCB concentrations in maternal blood during pregnancy. We aimed to investigate the effects of environmental prenatal exposure to OH-PCBs and reproductive hormone levels in cord blood, taking into account the maternal SNPs into account.169 mother-infant pairs registered to Sapporo cohort, the Hokkaido Study, were included in this analysis. In multiple linear regression models, significant inverse associations were found between maternal 4-OH-CB146+3-OH-CB153 and boy's sex hormone biding globulin (SHBG) in dose-response manner.Maternal 4-OH-CB187 level was associated with decreased girl's progesterone.There was no significant difference of OH-PCB levels or effect on hormones between each type of SNPs.

Research Products

• [Journal Article] Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health (2018)
  • Author(s): Mitsui Takahiko、Araki Atsuko、Goudarzi Houman、Miyashita Chihiro、Ito Sachiko、Sasaki Seiko、Kitta Takeya、Moriya Kimihiko、Cho Kazutoshi、Morioka Keita、Kishi Reiko、Shinohara Nobuo、Takeda Masayuki、Nonomura Katsuya
  • Journal Title: American Journal of Human Biology Volume: - Issue: 4
  • DOI: 10.1002/ajhb.23127
  • Peer Reviewed / Open Access
• [Journal Article] Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones: The Hokkaido Study on Environment and Children's Health (2018)
  • Author(s): Baba Toshiaki、Ito Sachiko、Yuasa Motoyuki、Yoshioka Eiji、Miyashita Chihiro、Araki Atsuko、Sasaki Seiko、Kobayashi Sumitaka、Kajiwara Jumboku、Hori Tsuguhide、Kato Shizue、Kishi Reiko
  • Journal Title: Science of the Total Environment Volume: 615 Pages: 1239-1246
  • DOI: 10.1016/j.scitotenv.2017.09.038
  • NAID: 120006796030
  • Peer Reviewed / Open Access
• [Journal Article] Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates: The Hokkaido Study on Environment and Children's Health. (2017)
  • Author(s): Minatoya M, Sasaki S, Araki A, Miyashita C, Itoh S, Yamamoto J, Matsumura T, Mitsui T, Moriya K, Cho K, Morioka K, Minakami H, Shinohara N, Kishi R.
  • Journal Title: Epidemiology. Volume: - Pages: S3-S9
  • DOI: 10.1097/ede.0000000000000716
  • NAID: 120006536947
  • Peer Reviewed / Open Access
• [Journal Article] Prenatal di(2-ethylhexyl) phthalate exposure and disruption of adrenal androgens and glucocorticoids levels in cord blood (2017)
  • Author(s): Araki, T. Mitsui, H. Goudarzi, T. Nakajima, C. Miyashita, S. Itoh, S. Sasaki, K. Cho, K. Moriya, N. Shinohara, K. Nonomura, R. Kishi
  • Journal Title: Science of the Total Environment Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study. (2017)
  • Author(s): Goudarzi H, Araki A, Itoh S, Sasaki S, Miyashita C, Mitsui T, Nakazawa H, Nonomura K, Kishi R.
  • Journal Title: Environ Health Perspect Volume: 125 Issue: 1 Pages: 111-118
  • DOI: 10.1289/ehp142
  • NAID: 120006533152
  • Peer Reviewed / Open Access
• [Journal Article] Association of perfluorinated chemical exposure in utero with maternal and infant thyroid hormone levels in the Sapporo cohort of Hokkaido Study on the Environment and Children's Health (2016)
  • Author(s): Kato, S., S. Itoh, M. Yuasa, T. Baba, C. Miyashita, S. Sasaki, S. Nakajima, A. Uno, H. Nakazawa, Y. Iwasaki, E. Okada, R. Kishi
  • Journal Title: Environ Health Prev Med Volume: 21 Issue: 5 Pages: 334-344
  • DOI: 10.1007/s12199-016-0534-2
  • NAID: 120006536946
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health. (2016)
  • Author(s): Itoh S, Araki A, Mitsui T, Miyashita C, Goudarzi H, Sasaki S, Cho K, Nakazawa H, Iwasaki Y, Shinohara N, Nonomura K, Kishi R.
  • Journal Title: Environ Int Volume: 94 Pages: 51-59
  • DOI: 10.1016/j.envint.2016.05.011
  • NAID: 120006523706
  • Peer Reviewed
• [Journal Article] Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido Study (2016)
  • Author(s): H. Goudarzi, S. Nakajima, T. Ikeno, S. Sasaki, S. Kobayashi, C. Miyashita, S. Ito, A. Araki, H. Nakazawa and R. Kishi
  • Journal Title: Sci Total Environ Volume: 541 Pages: 1002-1010
  • DOI: 10.1016/j.scitotenv.2015.10.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 【講座 子どもを取り巻く環境と健康】 第12回 環境化学物質曝露による内分泌系への影響（1）甲状腺機能 (2016)
  • Author(s): 伊藤佐智子、岸玲子
  • Journal Title: 医学書院 Volume: 80 Pages: 137-144
• [Journal Article] Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size (2015)
  • Author(s): C. Miyashita, S. Sasaki, T. Ikeno, A. Araki, S. Ito, J. Kajiwara, T. Todaka, N. Hachiya, A. Yasutake, K. Murata, T. Nakajima and R. Kishi
  • Journal Title: Sci Total Environ Volume: 533 Pages: 256-265
  • DOI: 10.1016/j.scitotenv.2015.06.108
  • Peer Reviewed / Open Access
• [Journal Article] Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children (2015)
  • Author(s): Mitsui T., Araki A., Imai A, Sato S., Miyashita C., Ito S., Sasaki S., Kitta T., Moriya K. Cho K., Morioka K., Kihsi R., Nonomura K
  • Journal Title: PLOS One Volume: 10(3) Issue: 3 Pages: e0120636-e0120636
  • DOI: 10.1371/journal.pone.0120636
  • NAID: 120005606031
  • Peer Reviewed / Open Access
• [Journal Article] The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Fatty Acids during Pregnancy and the Birth Weight of their Offspring:The Hokkaido Study (2015)
  • Author(s): Reiko Kishi, Tamie Nakajima, Houman Goudarzi, Sachiko Kobayashi, Seiko Sasaki, Emiko Okada, Chihiro Miyashita, Sachiko Itoh, Atsuko Araki, Tamiko Ikeno, Yusuke Iwasaki, and Hiroyuki Nakazawa
  • Journal Title: Environmental Health Perspective Volume: 印刷中 Issue: 10 Pages: 1038-1045
  • DOI: 10.1289/ehp.1408834
  • Peer Reviewed / Open Access
• [Presentation] Prenatal exposure to prganochlorine pesticides and steroid hormones profiles in fetal blood: The Hokkaido Study (2016)
  • Author(s): Araki, A., Miyashita, C., Mitui, T., Goudarzi, H., Itoh, S., Mizutani, F., Chisaki, Y., Sasaki, S., Moriya, K., Cho, K., Shinohara, N., Nonomura, K., Kishi, R
  • Organizer: PPTOX V
  • Place of Presentation: Kitakyushu International Conference Center, Kitakyushu, Japan
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] Effects of prenatal exposure to perfluoroalkyl acids on risk of allergic and infections diseases in early life (2016)
  • Author(s): Goudarzi, H., C. Miyashita, E. Okada, I. Kashino, S. Kobayashi, C.-J. Chen, S. Ito, A. Araki, H. Matsuura, R. Kishi
  • Organizer: ISEE2016: 28th Annual Conference International Society for Environmental Epidemiology
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-09-01
  • Int'l Joint Research
• [Presentation] Prenatal exposure to organochlorine pesticides and reproductive hormones in fetal blood: The Hokkaido Study (2016)
  • Author(s): Araki, A., C. Miyashita, S. Itoh, T. Mitsui, F. Mizutani, Y. Chisaki, S. Sasaki, K. Cho, K. Nonomura, R. Kishi
  • Organizer: ISEE2016: 28th Annual Conference International Society for Environmental Epidemiology
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-09-01
  • Int'l Joint Research
• [Presentation] Hokkaido Study on Environment and Children's Health: Endocrine Disruption Effect of Perfluoroalkyl Substances Exposure in Utero (2016)
  • Author(s): Itoh, S., A. Araki, C. Miyashita, H. Goudarzi, S. Kato, Y. Iwasaki, H. Nakazawa, N. Shinohara, R. Kishi
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Hokkaido University, Sapporo, Japan
  • Year and Date: 2016-06-26
  • Int'l Joint Research
• [Presentation] Effects of prenatal exposure to perfluoroalkyl acids on risk of allergic diseases at 4 years old children: The Hokkaido Study (2015)
  • Author(s): H. Goudarzi, S. Kobayashi, C. Chen, A. Araki, C. Miyashita, S. Ito and R. Kishi
  • Organizer: 第67回北海道公衆衛生学会
  • Place of Presentation: 旭川医科大学 (北海道・旭川市)
  • Year and Date: 2015-11-21
• [Presentation] 妊娠初期における北海道内女性労働者の記述疫学的考察 (2015)
  • Author(s): 小林澄貴, 宮下ちひろ, 荒木敦子, 池野多美子, 伊藤佐智子, H. Goudarzi, 花岡知之 , 岸玲子
  • Organizer: 平成27年度日本産業衛生学会北海道地方会 (第95回北海道医学大会産業衛生分科会)
  • Place of Presentation: 旭川建設労働者福祉センター (北海道・旭川市)
  • Year and Date: 2015-10-17
• [Remarks] 北海道大学 環境健康科学教育研究センター 研究業績
  • URL: http://www.cehs.hokudai.ac.jp/research/yearly/
• [Remarks] 環境と健康ひろば
  • URL: http://www.cehs.hokudai.ac.jp/hiroba/
• [Remarks] 環境と子どもに関する研究・北海道スタディ
  • URL: http://www.cehs.hokudai.ac.jp/hokkaidostudy/