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Construction of Unified Mathematical Model for Plane Cell Polarity

Research Project

Project/Area Number 15K20835
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Foundations of mathematics/Applied mathematics
Morphology/Structure
Research InstitutionHokkaido University

Principal Investigator

Akiyama Masakazu  北海道大学, 電子科学研究所, 助教 (10583908)

Research Collaborator YAMAZAKI Masakazu  秋田大学
AYUKAWA Tomonori  秋田大学
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords現象の数理モデル / 平面内細胞極性 / 数学解析 / 数理モデル / 数値計算 / 解の存在とその安定性 / Very slow dynamics / 精度保証付き数値計算
Outline of Final Research Achievements

In the development of organisms, sheet-like cells with a planar structure often deforms and creates tissues and organs. At this time, cells are properly aligned according to the rules (described later), and appropriate tissues and organs are created. That is, the rule is that each cell localizes a certain group of proteins asymmetrically and cooperates with surrounding cells. Such a phenomenon is called Planar Cell Polarity (PCP). Through this study, we were able to investigate the stability of patterns etc. by mathematically analyzing certain mathematical models of PCP.

Academic Significance and Societal Importance of the Research Achievements

PCPは1950年頃から,分子生物学的手法が発展することによってその分子メカニズムの研究が盛んに行われてきた.一方,そのようなミクロな分子がどのように協調して,全体としての極性を揃えているかという点に関しては未解明な点が残されていた.ブレークスルーとなったのは, K. Amonlirdviman氏等によるPCPに関する数理モデル(Science,2005)である.このモデルの詳細な解析および自身の構成した数理モデルとの比較および整合性等を数理的に解析した.

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016 2015

All Presentation (18 results) (of which Int'l Joint Research: 4 results,  Invited: 13 results)

  • [Presentation] A Mathematical Model of Planar Cell Polarity2018

    • Author(s)
      M.Akiyama,T.Ayukawa(Akita University), M.Yamazaki(Akita University)
    • Organizer
      2018 Annual Meeting of the Society for Mathematical Biology & the Japanese Society for Mathematical Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞極性と細胞移動の数理モデル2017

    • Author(s)
      秋山正和
    • Organizer
      数理生物研究会2017
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] A mathematical model of collective cell migration based on cell polarity2017

    • Author(s)
      M.Akiyama
    • Organizer
      A3-NIMS Joint Workshop on 「Interdisciplinary Research Connecting Mathematics and Biology」
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 数学のメガネで生物を見てみよう!2017

    • Author(s)
      秋山正和
    • Organizer
      第110回システム情報科学研究会(SSIセミナー)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] A Mathematical Analysis of Planar Cell Polarity Model2016

    • Author(s)
      M.Akiyama, T.Ayukawa、M.Yamazaki
    • Organizer
      H27年度電子科学研究所国際シンポジウム
    • Place of Presentation
      シャトレーゼ・ガトーキングダムサッポロ(北海道札幌市)
    • Year and Date
      2016-12-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 毛 の 方 向 が 一 方 向 に 揃 う 現 象 に 関 す る 数 理 モ デ ル2016

    • Author(s)
      秋山正和、山崎正和、鮎川友紀
    • Organizer
      第4回アライアンス若手研究交流会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-11-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Tetragonal versus hexagonal tiling of the Drosophila eye2016

    • Author(s)
      林貴史、秋山正和、佐藤純
    • Organizer
      12th Japanese Drosophila Research Conference(第12回 日本ショウジョウバエ研究会)
    • Place of Presentation
      立教大学(東京都豊島区)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 平面内細胞極性の数理モデル2016

    • Author(s)
      秋山正和、鮎川友紀、山秋正和
    • Organizer
      数理で解き明かす森羅万象
    • Place of Presentation
      広島大学(広島県東広島市)
    • Year and Date
      2016-08-20
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] A Mathematical Model of Planar Cell Polarity2016

    • Author(s)
      M.Akiyama, T.Ayukawa, M.Yamazaki
    • Organizer
      International Conference: Patterns and Waves 2016
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-08-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 平面内細胞極性の数理モデル2016

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      基生研研究会「物理学は生物現象の謎を解けるか」
    • Place of Presentation
      基礎生物学研究所(愛知県岡崎市)
    • Year and Date
      2016-01-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 平面内細胞極性の数理モデル2015

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      応用数学合同研究集会
    • Place of Presentation
      龍谷大学(滋賀県大津市)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 平面内細胞極性の数理モデル2015

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      共同利用・共同研究拠点 MIMS 現象数理学拠点 共同研究集会「自然、社会に現れる複雑現象の数理」
    • Place of Presentation
      明治大学(東京都中野区)
    • Year and Date
      2015-10-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] A Mathematical Model of Planar Cell Polarity2015

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      Mini-workshop on Collaborative study with mathematics and biology for dermatology
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 平面内細胞極性の数理モデル2015

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      応用数理学会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
  • [Presentation] A Mathematical Model of Planar Cell Polarity2015

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      国際学会ICIAM2015
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-08-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 平面内細胞極性の数理モデル2015

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      N.L.P.M. コロキウム
    • Place of Presentation
      広島大学(広島県東広島市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] A Mathematical Model of Planar Cell Polarity2015

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      Mini-workshop on “A crossroad of biology and mathematics -Model and Computation-”
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 平面内細胞極性の数理モデル2015

    • Author(s)
      秋山正和, 鮎川友紀, 山崎正和
    • Organizer
      京都駅前セミナー
    • Place of Presentation
      キャンパスプラザ京都(京都府京都駅前)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2020-03-30  

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