Elucidation of mechanisms by which host immune cells kill protozoan parasites and development of antiparasitic peptides
| Project/Area Number |
15K20840
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Terkawi Alaa 北海道大学, 医学研究科, 助教 (00723074)
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| Research Collaborator |
Kato Kentaro 原虫病研究センター帯広畜産大学
Takano Ryo 原虫病研究センター帯広畜産大学
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Macrophages / Neutrophils / Phagocytes / Effector molecules / neutrophils / effector molecules / DNA Microarray / DEFB130 / CTSL |
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| Outline of Final Research Achievements |
Understanding the molecular defense mechanism of phagocytes and identifying their effector molecules against malarial parasites may provide important clues for the discovery of new therapies. Macrophages and neutrophils are professional phagocytes that play key role in the innate immune response against infection through their ability to rapidly recognize and kill microorganisms. An attempt was made to identify the host effector molecules derived from macrophages and neutrophils that kill malaria parasites using DNA microarray technology.
Results suggested that DEFB130 from macrophages and CTSL from neutrophils are involved in the clearance mechanism of malarial parasites. The data obtained from this project broaden our knowledge on the immunological response of macrophages and neutrophils to malaria parasites and shed light on a new target for therapeutic intervention.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Molecular detection and characterization of Babesia bovis, Babesia bigemina, Theileria species and Anaplasma marginale isolated from cattle in Kenya.2015
Author(s)
Adjou Moumouni PF, Aboge GO, Terkawi MA, Masatani T, Cao S, Kamyingkird K, Jirapattharasate C, Zhou M, Wang G, Liu M, Iguchi A, Vudriko P, Ybanez AP, Inokuma H, Shirafuji-Umemiya R, Suzuki H, Xuan X.
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Journal Title
Parasites & Vectors
Volume: 8
Issue: 1
Pages: 496-496
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites.2015
Author(s)
Rizk, M.A., El-Sayed, S.A., Terkawi, M.A., Youssef, M.A., El Said el Sel, S., Elsayed, G., El-Khodery, S., El-Ashker, M., Elsify, A., Omar, M., Salama, A., Yokoyama, N., and Igarashi, I.
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Journal Title
PLoS One.
Volume: 10
Issue: 4
Pages: e0125276-e0125276
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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