Involvement of the medial prefrontal cortex in stress vulnerability induced by early life stress
| Project/Area Number |
15K20846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental psychology
Psychiatric science
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 幼少期ストレス / ストレス脆弱性 / 内側前頭前野 / 大脳半球間抑制 / 大脳半球間連絡 |
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| Outline of Final Research Achievements |
In this study, we investigated the involvement of the medial prefrontal cortex (mPFC) activity in stress vulnerability in mice subjected to maternal separation stress. Mice subjected to postnatal maternal separation stress showed increases in open-field anxiety and social-anxiety after maturation. The optogenetic activation of neurons in the left mPFC which projected to the right mPFC reduced open-field anxiety but increased social anxiety. These results suggest that the mPFC is influenced by postnatal maternal separation stress and that the interaction between the left and right mPFC might be differently involved in modulation of anxiety induced by novel environment and social environment.
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Report
(4 results)
Research Products
(5 results)
