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Toward the World's First Tumor-Following Radiation Therapy Technique: Development of High-Accuracy Tumor Tracking System

Research Project

Project/Area Number 15K20852
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Life / Health / Medical informatics
Research InstitutionTohoku University

Principal Investigator

Zhang Xiaoyong  東北大学, 工学研究科, 助教 (90722752)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords画像誘導放射線治療 / マーカレス追尾 / MVX線画像 / Radiation Therapy / Markerless Tracking / Radiographic Imaging / Radiation therapy / Radiographic imaging / Tumor tracking
Outline of Final Research Achievements

The purpose of this research is to develop a radiographic image tracking system to track respiration-induced tumor motion in real-time for adaptive tumor following radiation therapy. The tracking system will be able to provide conformable tumor motion information and allows the treatment device to accurately deliver high-dose conformable radiation to the moving target during the treatment.
In this research project, a kernel-based algorithm and a level set method-based method have been developed for tracking the tumor’s position and its boundary in kilo-voltage (kV) images and megavoltage (MV) images. The experimental results performed on the phantom and clinical data sets demonstrated the effectiveness of the systems for clinical application.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (16 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Tracking Tumor Boundary in MV-EPID Images Without Implanted Markers: A Feasibility Study2015

    • Author(s)
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Yoshihiro Takai, Yuichiro Narita, Makoto Yoshizawa
    • Journal Title

      Medical Physics

      Volume: 42 Issue: 5 Pages: 2510-2523

    • DOI

      10.1118/1.4918578

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Is Mammographic Breast Density a Risk Factor for Breast Cancer in Japanese Women?2015

    • Author(s)
      Xiaoyong Zhang, Norimasa Chikushima, Atsutoshi Watanabe, Yuji Ohashi, Nao Hasegawa, Kei Ichijii, Atsushi Tamura, Makoto Osanai, Noriyasu Homma,
    • Journal Title

      Bulletin of School of Health Sciences Tohoku University

      Volume: 24 Pages: 45-51

    • NAID

      120005578868

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 乳房X線画像の乳房密度評価への胸筋領域の影響:正常例での胸筋の有無による乳房密度の比較2017

    • Author(s)
      魚住洋佑,張暁勇,市地慶,高根侑美,川住祐介,石橋忠司,本間経康
    • Organizer
      第50回日本生体医工学会東北支部大会
    • Place of Presentation
      東北大学(仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Statistical Analysis of Bilateral Breast Density Differences of Mammogram for Breast Cancer Risk Assessment2017

    • Author(s)
      Jiaqi Chen, Xiaoyong Zhang, Noriyasu Homma
    • Organizer
      第50回日本生体医工学会東北支部大会
    • Place of Presentation
      東北大学(仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Deep Convolutional Neural Networkの転移学習による乳房X線画像上の腫瘤検出2017

    • Author(s)
      鈴木 真太郎,張 暁勇,本間 経康,吉澤 誠
    • Organizer
      計測自動制御学会東北支部第307回研究集会
    • Place of Presentation
      東北大学(仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Deep Convolutional Neural Network を用いた乳房X線画像上の病変検出2016

    • Author(s)
      鈴木真太郎,張 暁勇,本間経康,市地慶,魚住洋佑,高根侑美,川住祐介,石橋 忠司,吉澤 誠
    • Organizer
      SICE第10回コンピュテーショナル・インテリジェンス研究会
    • Place of Presentation
      富山県民会館(富山県)
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] A Real-Time Homography-Based Tracking Method for Tracking Deformable Tumor Motion in Fluoroscopy2016

    • Author(s)
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Norihiro Sugita, Yoshihiro Takai, Makoto Yoshizawa
    • Organizer
      SICE Annual Conference 2016
    • Place of Presentation
      Tsukuba International Congress Center (Tsukuba)
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mass Detection Using Deep Convolutional Neural Network for Mammographic Computer-Aided Diagnosis2016

    • Author(s)
      Shintaro Suzuki, Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Norihiro Sugita, Yusuki Kawasumi, Tadashi Ishibashi, Makoto Yoshizawa
    • Organizer
      SICE Annual Conference 2016
    • Place of Presentation
      Tsukuba International Congress Center (Tsukuba)
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Mammographic Mass Detection Method Based on Transfer Learning of Deep Convolutional Neural Network2016

    • Author(s)
      Shintaro Suzuki, Xiaoyong Zhang, Noriyasu Homma, Makoto Yoshizawa
    • Organizer
      平成28年度電気関係学会東北支部連合大会
    • Place of Presentation
      東北工業大学(仙台市)
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection of Mass on Mammograms Using Deep Convolutional Neural Network: A Feasibility Study2016

    • Author(s)
      Shintaro Suzuki, Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Norihiro Sugita, Yusuki Kawasumi, Tadashi Ishibashi, Makoto Yoshizawa
    • Organizer
      American Association of Physicists in Medicine 58th Annual Meeting (AAPM2016)
    • Place of Presentation
      Walter E. Washington Convention Center (Washington, DC)
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 呼吸性移動時系列の最大リャプノフ指数推定に基づく予測可能性の検討2015

    • Author(s)
      市地慶, 本間経康, 張曉勇, 武田賢, 髙井良尋 , 杉田典大, 吉澤誠
    • Organizer
      2015計測自動制御学会システム・情報部門学術講演会
    • Place of Presentation
      函館アリーナ(北海道・函館市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Tumor Motion Tracking Using kV/MV X-Ray Fluoroscopy for Adaptive Radiation Therapy2015

    • Author(s)
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Norihiro Sugita, Yoshihiro Takai, Makoto Yoshizawa
    • Organizer
      2015計測自動制御学会システム・情報部門学術講演会
    • Place of Presentation
      函館アリーナ(北海道・函館市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Tumor Motion Tracking Using kV/MV X-Ray Fluoroscopy for Adaptive Radiation Therapy2015

    • Author(s)
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Makoto Abe, Norihiro Sugita, Ivo Bukovsky, Yoshihiro Takai, Makoto Yoshizawa
    • Organizer
      2015 International Workshop on Computational Intelligence for Multimedia Understanding
    • Place of Presentation
      Prague (Czech Republic)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Real-Time Feature-Based Markerless Tumor Tracking Method Using X-Ray Image Sequence for Radiotherapy2015

    • Author(s)
      Yusuke Yoshida, Kei Ichiji, Xiaoyong Zhang, Noriyasu Homma, Yoshihiro Takai, Makoto Yoshizawa
    • Organizer
      2015 International Workshop on Computational Intelligence for Multimedia Understanding
    • Place of Presentation
      Prague (Czech Republic)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Real-Time Homography-Based Algorithm for Markerless Deformable Lung Tumor Motion Tracking Using kV X-Ray Fluoroscopy2015

    • Author(s)
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Norihiro Sugita, Yoshihiro Takai, Makoto Yoshizawa
    • Organizer
      第25回インテリジェント・システム・シンポジウム
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 赤外線深度センサを用いた体表面同時多点の呼吸誘導システムに関する研究2015

    • Author(s)
      塚田拓也,市地慶,張曉勇,本間経康,髙井良尋,吉澤誠
    • Organizer
      第25回インテリジェント・システム・シンポジウム
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] A Real-Time Homography-Based Algorithm for Markerless Deformable Lung Tumor Motion Tracking Using kV X-Ray Fluoroscopy2015

    • Author(s)
      Xiaoyong Zhang, Noriyasu Homma, Yuichiro Narita, Yoshihiro Takai, Kei Ichiji, Makoto Abe, Norihiro Sugita, Makoto Yoshizawa
    • Organizer
      2015 American Association of Physicists in Medicine 57th Annual Meeting
    • Place of Presentation
      Anaheim (USA)
    • Year and Date
      2015-07-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 乳房 X 線画像診断支援のための多層自己組織化マップによる自動特徴分類の試み2015

    • Author(s)
      長谷川奈保,本間経康,張暁勇,市地慶,小山内実,阿部誠,杉田典大,吉澤誠
    • Organizer
      計測自動制御学会第7回コンピューテーショナル・インテリジェンス研究会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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