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The assessment of the effectiveness and safety of seasonal influenza vaccine among Japanese pregnant women and children

Research Project

Project/Area Number 15K20862
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Epidemiology and preventive medicine
Research InstitutionTohoku University

Principal Investigator

OBARA Taku  東北大学, 大学病院, 准教授 (80612019)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords医薬品情報・安全性学 / 予防医学
Outline of Final Research Achievements

In Japan, information on the effectiveness and safety of seasonal influenza vaccine among pregnant women and infants has not been available, differently from foreign countries. The aim of the present study was to evaluate the efficacy and safety of injection of influenza vaccine among pregnant women and infants in Japan based on the established study basements. In the babies' and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI) study and the Japan Environment and Children's Study (JECS), we completely collected the information on the injection of influenza vaccination among pregnant women and continued the follow-up survey for infants. We also clarified that the prevalence of infants who received influenza vaccine, that of infected by influenza virus, and had an experience of adverse drug reaction by influenza vaccination were not different between influenza seasons from 2015 to 2017.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (8 results) (of which Invited: 5 results)

  • [Journal Article] Drug Use before and during Pregnancy in Japan: The Japan Environment and Children’s Study2017

    • Author(s)
      Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Satoshi Mizuno, Kasumi Sakurai, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Shinichi Kuriyama, Nobuo Yaegashi and Japan Environment & Children’s Study Group
    • Journal Title

      Pharmacy

      Volume: -

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 本邦の妊婦における医薬品使用の安全性評価2015

    • Author(s)
      小原 拓
    • Journal Title

      医薬品相互作用研究

      Volume: 39 Pages: 1-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 医療従事者におけるインフルエンザ4価ワクチン接種の安全性と有効性の評価2017

    • Author(s)
      赤坂和俊、小原拓、遠藤史郎、池田しのぶ、十日市文子、鈴木博也、久道周彦、山口浩明、賀来満夫、眞野成康
    • Organizer
      第27回日本医療薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児におけるインフルエンザ4価ワクチン接種の安全性と有効性の評価2017

    • Author(s)
      小原拓、柿崎周平、赤坂和俊、鈴木洋一、栗山進一、佐藤恒明、小松和久、眞野 成康
    • Organizer
      医療薬学フォーラム2017第25回クリニカルファーマシーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 薬剤師による医薬品安全性情報の創出」医薬品・医療機器等安全性情報報告制度の運用の現状と課題2017

    • Author(s)
      小原拓、眞野成康
    • Organizer
      第27回日本医療薬学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 「副作用報告の推進に向けての薬・薬連携」病院における医薬品・医療機器等安全性情報報告制度への対応2017

    • Author(s)
      小原拓、眞野成康
    • Organizer
      第50回日本薬剤師会学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 医薬品・医療機器等安全性情報報告制度と医薬品安全性情報の創出2017

    • Author(s)
      小原拓、眞野成康
    • Organizer
      医療薬学フォーラム2017第25回クリニカルファーマシーシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 薬剤師によるエビデンスの評価・創出のために2016

    • Author(s)
      小原 拓
    • Organizer
      第146回宮城県病院薬剤師会学術研究発表会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-03-06
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 知っておくべき妊娠と薬の知識 -妊娠と薬外来の経験から-2016

    • Author(s)
      小原 拓
    • Organizer
      第4回妊婦授乳婦薬物療法研修会
    • Place of Presentation
      TKPガーデンシティ仙台(宮城県仙台市)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 小児におけるインフルエンザワクチンの有効性に関する検討:埼玉県蕨戸田市医師会調査2014-2015年2016

    • Author(s)
      松田 彩子、浅山 敬、小原 拓、八木 直人、大久保 孝義
    • Organizer
      第26回日本疫学会学術総会
    • Place of Presentation
      米子コンベンションセンターBigShip(鳥取県米子市)
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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