| Project/Area Number |
15K20890
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
Molecular biology
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Naganuma Takao 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (40466462)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 非コードRNA / 脱ユビキチン化酵素 / RNA結合 / 脱ユビキチン化 / RNA結合タンパク質 |
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| Outline of Final Research Achievements |
We found that USP10, which is the one of deubiquitinase, interacts with some ncRNAs and mRNAs, and identified the RNA binding region of USP10. By analyzing the precise interaction between USP10 and HNRNPK, we also found that RNAs mediate the interaction between them. The knockdown of USP10 with siRNA showed that USP10 deubiquitinates HNRNPK within the cell. However, both the significance that USP10 interacts with RNAs and the functional roles that USP10 deubiquitinates HNRNPK within the cell remain to be elucidated.
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