| Project/Area Number |
15K20894
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
Cardiovascular medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Kuroki Kenji 筑波大学, 附属病院, 病院講師 (50726940)
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| Research Collaborator |
AONUMA KAZUTAKA 筑波大学, 医学医療系, 教授
SEKIGUCHI YUKIO 筑波大学, 医学医療系, 准教授
IGARASHI MIYAKO 筑波大学, 医学医療系, 講師
MURAKOSHI NOBUYUKI 筑波大学, 医学医療系, 講師
KYO TOSHU 筑波大学, 医学医療系, 助教
ISAKA YUMI 筑波大学, 医学医療系, 専門職員
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 次世代シークエンサー / Ｊ波症候群 / J波症候群 / 心室細動 / 突然死 / 遺伝子 |
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| Outline of Final Research Achievements |
The purpose of this study is to reveal the genetic abnormality of J wave syndrome (Brugada syndrome and early repolarization syndrome (ERS)), and to use it for the prevention and treatment of the sudden death from ventricular arrhythmias.
(1)Genetic abnormality was found in 3 of 27 patients with Brugada syndrome.
(2)Comprehensive genetic analysis was performed in 4 patients with Brugada syndrome who had no SCA5A genetic abnormality, 2 patients with ERS, and 6 patients with idiopathic ventricular fibrillation (IVF). Genetic abnormality was found in 2 IVF patients (SCN5A、TBX5), and new genetic abnormality was found in a ERS patient.
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