DNA methylation and demethylation in the hypothalamic feeding center

• Project/Area Number: 15K20903
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology); General physiology
• Research Institution: Gunma University
• Principal Investigator: Kohno Daisuke 群馬大学, 先端科学研究指導者育成ユニット, 助教 (10382904)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: DNAメチル化 / 視床下部 / 肥満 / DNMT3a / TET1 / チロシン水酸化酵素

Outline of Final Research Achievements

We previously reported that DNA methyltransferase 3a (DNMT3a) in the hypothalamic feeding center plays indispensable role in energy homeostasis. In this study, we found that tyrosine hydroxylase (TH) expression in the hypothalamus is necessary for the development of obesity in mice lacking DNMT3a in the hypothalamic feeding center.